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Gene Review:

NUG1 - RNA-binding GTPase NUG1

Saccharomyces cerevisiae S288c

Synonyms: Nuclear GTP-binding protein NUG1, Nuclear GTPase 1, YER006W

Tartakoff, A.M. et al., Bassler, J. et al., Nicolás, F.J. et al., Ouspenski, I.I.

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High impact information on NUG1

This nuclear GTPase and its homologues are known in both yeasts and higher organisms and in all cases they are regulated by guanine-nucleotide-exchange factors [1].
The 'nuclear GTPase cycle' created by these components is implicated in mRNA transport from and protein import to the nucleus, as well as in DNA replication, RNA processing and the regulation of the cell cycle [1].
Our findings suggest that Nug1 associates with pre-60 S subunits via its essential N-terminal RNA-binding domain and exerts a non-essential regulative role in pre-60 S subunit biogenesis via its central GTPase domain [2].
The conserved Nug1 C-domain, which has a yet uncharacterized fold, is also essential for ribosome biogenesis [2].
Ran is a nuclear GTPase implicated in nucleocytoplasmic transport, the maintenance of nuclear structure, mRNA processing, and cell cycle regulation [3].

Biological context of NUG1

Ran, a nuclear GTPase, and a number of interacting proteins, including regulators RanGEF1 and RanGAP1, are involved in nucleocytoplasmic transport [4].

References

The nuclear GTPase cycle: promoting peripheralization? Tartakoff, A.M., Schneiter, R. Trends Cell Biol. (1995) [Pubmed]
The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. Bassler, J., Kallas, M., Hurt, E. J. Biol. Chem. (2006) [Pubmed]
Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts. Nicolás, F.J., Zhang, C., Hughes, M., Goldberg, M.W., Watton, S.J., Clarke, P.R. J. Cell. Sci. (1997) [Pubmed]
A RanBP1 mutation which does not visibly affect nuclear import may reveal additional functions of the ran GTPase system. Ouspenski, I.I. Exp. Cell Res. (1998) [Pubmed]

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AGOS_ADR008W	Ashbya gossypii ATCC 10895
KLLA0D13618g	Kluyveromyces lactis NRRL Y-1140
MGG_17514	Magnaporthe oryzae 70-15
NCU03066	Neurospora crassa OR74A
grn1	Schizosaccharomyces pombe 972h-

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