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Gene Review

FIR1  -  Fir1p

Saccharomyces cerevisiae S288c

Synonyms: Factor interacting with REF2, PAP1-interacting protein, PIP1, Polymerase-interacting protein 1, YER032W
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High impact information on FIR1

  • It directly interacts with Fir1p, a component of the cleavage/polyadenylation complex [1].
  • Kinetic analyses of the respective polyadenylation reactions indicated that Pbp1p is a negative regulator of poly(A) nuclease (PAN) activity and that Fir1p and Ref2p are, respectively, a positive regulator and a negative regulator of poly(A) synthesis [2].


  1. Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p. Hershkovits, G., Bangio, H., Cohen, R., Katcoff, D.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Identification of factors regulating poly(A) tail synthesis and maturation. Mangus, D.A., Smith, M.M., McSweeney, J.M., Jacobson, A. Mol. Cell. Biol. (2004) [Pubmed]
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