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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RGS11  -  regulator of G-protein signaling 11

Homo sapiens

Synonyms: Regulator of G-protein signaling 11
 
 
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High impact information on RGS11

  • A single intracerebroventricular (i.c.v.) ED(80) analgesic dose of morphine gave rise to acute tolerance in control mice, but did not promote tolerance in RGS6, RGS7, RGS9-2, or RGS11 knockdown animals [1].
  • Gbeta5 could also interact with RGS11 and its N-terminal, but not its C-terminal domain [2].
 

Analytical, diagnostic and therapeutic context of RGS11

  • The duration of morphine analgesia was greatly increased in RGS9-2 and in RGS11 knockdown mice [1].

References

  1. The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors. Garzón, J., López-Fando, A., Sánchez-Blázquez, P. Neuropsychopharmacology (2003) [Pubmed]
  2. Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: gain of function of cyan fluorescent protein-tagged G gamma 3. Zhou, J.Y., Toth, P.T., Miller, R.J. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
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