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Gene Review

Rgs11  -  regulator of G-protein signaling 11

Mus musculus

Synonyms: C78048, Regulator of G-protein signaling 11
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High impact information on Rgs11

  • RGS7 and RGS11 present in this neural structure showed no association with MOR [1].
  • At 2 h after administering the acute opioid, RGS7 mRNA levels in the striatum plus those of RGS9-2 in the striatum and thalamus were increased, whereas RGS9-2 and RGS11 mRNA were reduced in the cortex [2].
  • At 2 days after commencing sustained morphine treatment, the levels of mRNA for RGS7, RGS9-2, RGS11, and Gbeta5 increased in most of the brain structures studied (striatum, thalamus, periaqueductal gray matter (PAG), and cortex) [2].

Analytical, diagnostic and therapeutic context of Rgs11


  1. Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization. Garzón, J., Rodríguez-Muñoz, M., López-Fando, A., Sánchez-Blázquez, P. J. Biol. Chem. (2005) [Pubmed]
  2. Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine. López-Fando, A., Rodríguez-Muñoz, M., Sánchez-Blázquez, P., Garzón, J. Neuropsychopharmacology (2005) [Pubmed]
  3. Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. Rahman, Z., Gold, S.J., Potenza, M.N., Cowan, C.W., Ni, Y.G., He, W., Wensel, T.G., Nestler, E.J. J. Neurosci. (1999) [Pubmed]
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