Disease relevance of algQ

• In a reconstituted E. coli system, PvdS-dependent transcription from the pvdA promoter was doubled by the multicopy algQ gene [1].
• The algR2 (also known as algQ) gene of Pseudomonas aeruginosa has previously been identified as being necessary for alginate production at 37 degrees C. We have cloned two genes, from a cosmid library of Escherichia coli, which can restore mucoidy to an algR2 mutant of P. aeruginosa [2].

High impact information on algQ

• An increased intracellular concentration of RpoD mimicked the DeltaalgQ phenotype, whereas PvdS overexpression suppressed the algQ mutation [1].
• A novel genetic element, algP, was identified immediately downstream of algQ [3].
• The algQ gene encodes an acidic 18-kilodalton polypeptide required for transcriptional activation of the algD gene [3].
• DNA sequence and expression analysis of algP and algQ, components of the multigene system transcriptionally regulating mucoidy in Pseudomonas aeruginosa: algP contains multiple direct repeats [3].
• The algQ gene was found closely linked to the previously identified algR gene [4].

Biological context of algQ

• The complete nucleotide sequence of a 3.2-kilobase-pair chromosomal region containing the algP and algQ genes was determined [3].

References