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Gene Review:

mshD - mycothiol acetyltransferase

Mycobacterium tuberculosis H37Rv

Koledin, T. et al., Vetting, M.W. et al.

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Disease relevance of Rv0819

Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases [1].
Cloning and expression of mshD from M. tuberculosis (Rv0819) in Escherichia coli gave a transformant with MshD activity, demonstrating that Rv0819 is the mshD mycothiol biosynthesis gene [2].

High impact information on Rv0819

Sequencing outward of the DNA of the mutant strain from the site of insertion permitted identification of the mshD gene in the M. smegmatis genome, as well as the orthologous gene Rv0819 in the M. tuberculosis genome [2].

References

Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases. Vetting, M.W., Roderick, S.L., Yu, M., Blanchard, J.S. Protein Sci. (2003) [Pubmed]
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Koledin, T., Newton, G.L., Fahey, R.C. Arch. Microbiol. (2002) [Pubmed]

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