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Gene Review:

espJ - ESX-1 secretion-associated protein EspJ

Mycobacterium tuberculosis H37Rv

Liu, X.Q. et al., Brock, I. et al., Brusasca, P.N. et al., Agger, E.M. et al.

Agger, Brock, Okkels, Arend, Aagaard, Weldingh, Andersen,

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Disease relevance of Rv3878

We have performed a rigorous assessment of the diagnostic potential of four recently identified antigens (Rv2653, Rv2654, Rv3873, and Rv3878) from genomic regions that are lacking from the Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine strains as well as from the most common nontuberculous mycobacteria [1].
The six proteins (Rv3871, Rv3872, Rv3873, MTSA-10, ESAT-6 and Rv3878) were purified to near-homogeneity from recombinant Escherichia coli [2].

High impact information on Rv3878

Forty-five percent (95% confidence interval [CI], 31 to 57%) and 53% (95% CI, 39 to 67%) of the tuberculosis patients responded to Rv3879c and Rv3873, respectively, identifying these proteins as major M. tuberculosis T-cell antigens in humans, while 35 and 25% of the patients responded to Rv3878 and Rv1989c, respectively [3].
Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis [4].

References

Specific T-cell epitopes for immunoassay-based diagnosis of Mycobacterium tuberculosis infection. Brock, I., Weldingh, K., Leyten, E.M., Arend, S.M., Ravn, P., Andersen, P. J. Clin. Microbiol. (2004) [Pubmed]
Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome. Brusasca, P.N., Colangeli, R., Lyashchenko, K.P., Zhao, X., Vogelstein, M., Spencer, J.S., McMurray, D.N., Gennaro, M.L. Scand. J. Immunol. (2001) [Pubmed]
Evaluation of T-cell responses to novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection. Liu, X.Q., Dosanjh, D., Varia, H., Ewer, K., Cockle, P., Pasvol, G., Lalvani, A. Infect. Immun. (2004) [Pubmed]
Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis. Agger, E.M., Brock, I., Okkels, L.M., Arend, S.M., Aagaard, C.S., Weldingh, K.N., Andersen, P. Immunology (2003) [Pubmed]

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