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Gene Review:

rmlC - dTDP-4-dehydrorhamnose 3,5-epimerase

Mycobacterium tuberculosis H37Rv

Kantardjieff, K.A. et al., Li, W. et al.

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Disease relevance of rmlC

The Mycobacterium tuberculosis rmlC gene encodes dTDP-4-keto-6-deoxyglucose epimerase, the third enzyme in the M. tuberculosis dTDP-L-rhamnose pathway which is essential for mycobacterial cell-wall synthesis [1].

High impact information on rmlC

We generated M. smegmatis rmlB gene knockout mutant (transcription of downstream rmlC gene was blocked because of a polar effect) by homologous recombination [2].
Because it is structurally unique, highly substrate-specific and does not require a cofactor, RmlC is considered to be the most promising drug target in the pathway, and the M. tuberculosis rmlC gene was selected in the initial round of TB Structural Genomics Consortium targets for structure determination [1].

References

Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway. Kantardjieff, K.A., Kim, C.Y., Naranjo, C., Waldo, G.S., Lekin, T., Segelke, B.W., Zemla, A., Park, M.S., Terwilliger, T.C., Rupp, B. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
rmlB and rmlC genes are essential for growth of mycobacteria. Li, W., Xin, Y., McNeil, M.R., Ma, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]

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