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Gene Review

guaA  -  GMP synthase

Mycobacterium tuberculosis H37Rv

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Disease relevance of guaA

  • A novel transcriptional regulator has been identified in the 400-bp upstream region of the guaA gene of Mycobacterium tuberculosis H37Rv that promotes the expression of lacZ gene in Mycobacterium smegmatis mc(2)155 and M. tuberculosis H37Rv but not in Escherichia coli DH5alpha [1].

High impact information on guaA

  • PCR-mediated deletion mutagenesis and cloning identified a 120-bp fragment upstream from the guaA gene to be the actual regulator [1].
  • Primer extension analysis mapped the transcription start site to be the first 'G' residue of the translation start codon GTG of the guaA gene [1].


  1. Identification of a novel mycobacterial transcriptional regulator and its involvement in growth rate dependence and stringent control. Kamalakannan, V., Ramachandran, G., Narayanan, S., Vasan, S.K., Narayanan, P.R. FEMS Microbiol. Lett. (2002) [Pubmed]
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