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Gene Review

DDX18  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 18

Homo sapiens

Synonyms: ATP-dependent RNA helicase DDX18, DEAD box protein 18, MrDb, Myc-regulated DEAD box protein
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High impact information on DDX18

  • In addition, as for c-Myc, the expression of MrDb is induced upon proliferative stimulation of primary human fibroblasts as well as B cells and down-regulated during terminal differentiation of HL60 leukemia cells [1].


  1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. Grandori, C., Mac, J., Siëbelt, F., Ayer, D.E., Eisenman, R.N. EMBO J. (1996) [Pubmed]
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