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Gene Review:

gmd - GDP-D-mannose dehydratase

Helicobacter pylori J99

Järvinen, N. et al., Mäki, M. et al.

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High impact information on gmd

Previous success in functional expression of bacterial gmd genes in S. cerevisiae allowed us to convert GDP-D-mannose into GDP-4-keto-6-deoxy-D-mannose [1].
Here, we cloned the two key enzymes of GDP-l-fucose synthesis, H. pylori gmd coding for GDP-d-mannose dehydratase (GMD), and gmer coding for GDP-4-keto-6-deoxy-d-mannose-3,5-epimerase/4-reductase (GMER) and expressed them in an enzymatically active form in Saccharomyces cerevisiae [2].

References

Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose. Mäki, M., Järvinen, N., Räbinä, J., Roos, C., Maaheimo, H., Renkonen, R. Eur. J. Biochem. (2002) [Pubmed]
Cloning and expression of Helicobacter pylori GDP-l-fucose synthesizing enzymes (GMD and GMER) in Saccharomyces cerevisiae. Järvinen, N., Mäki, M., Räbinä, J., Roos, C., Mattila, P., Renkonen, R. Eur. J. Biochem. (2001) [Pubmed]

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