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Gene Review

HSPB3  -  heat shock 27kDa protein 3

Homo sapiens

Synonyms: DHMN2C, HMN2C, HSP 17, HSP27, HSPL27, ...
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Disease relevance of HSPB3

  • 0. We have expressed the HSPL27 in E. coli and the expressed protein was found to be present in the soluble fraction of the bacterial cell lysate [1].

High impact information on HSPB3

  • Especially, the expressions of HSPB3, identified for the first time as a 17-kDa protein in this paper, and MKBP/HSPB2 are distinctly specific to muscles [2].
  • Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3 [3].
  • Two of the genes (HspB3 and HspB9) are intronless, and the others have 1 or 2 introns at various positions [4].
  • The HspB3 cDNA is 742 bp long and contains an open reading frame specifying a polypeptide of 150 amino acid residues [5].
  • Chromosomal mapping data shows that the HSPL27 gene is located at human chromosome 5q11.2 [1].

Analytical, diagnostic and therapeutic context of HSPB3

  • Sequence analysis has shown that the putative novel smhsp, named 27 kDa heat-shock-protein-like protein (HSPL27) is a protein of 241 amino acids with a deduced molecular mass of 26.7 kDa and a deduced pI of 8 [1].


  1. Isolation and characterization of a human heart cDNA encoding a new member of the small heat shock protein family--HSPL27. Lam, W.Y., Wing Tsui, S.K., Law, P.T., Luk, S.C., Fung, K.P., Lee, C.Y., Waye, M.M. Biochim. Biophys. Acta (1996) [Pubmed]
  2. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. Sugiyama, Y., Suzuki, A., Kishikawa, M., Akutsu, R., Hirose, T., Waye, M.M., Tsui, S.K., Yoshida, S., Ohno, S. J. Biol. Chem. (2000) [Pubmed]
  3. Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3. Fontaine, J.M., Sun, X., Benndorf, R., Welsh, M.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  4. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. Kappé, G., Franck, E., Verschuure, P., Boelens, W.C., Leunissen, J.A., de Jong, W.W. Cell Stress Chaperones (2003) [Pubmed]
  5. HspB3, the most deviating of the six known human small heat shock proteins. Boelens, W.C., Van Boekel, M.A., De Jong, W.W. Biochim. Biophys. Acta (1998) [Pubmed]
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