Gene Review:
HSPB2 - heat shock 27kDa protein 2
Homo sapiens
Synonyms:
DMPK-binding protein, HSP27, Heat shock protein beta-2, Hs.78846, HspB2, ...
- Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines. Yonekura, N., Yokota, S., Yonekura, K., Dehari, H., Arata, S., Kohama, G., Fujii, N. Cell Death Differ. (2003)
- Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival. Shimura, H., Miura-Shimura, Y., Kosik, K.S. J. Biol. Chem. (2004)
- Ischemia-induced increase of stiffness of alphaB-crystallin/HSPB2-deficient myocardium. Golenhofen, N., Redel, A., Wawrousek, E.F., Drenckhahn, D. Pflugers Arch. (2006)
- Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander disease. Head, M.W., Corbin, E., Goldman, J.E. Am. J. Pathol. (1993)
- Dementia, gliosis and expression of the small heat shock proteins hsp27 and alpha B-crystallin in Parkinson's disease. Renkawek, K., Stege, G.J., Bosman, G.J. Neuroreport (1999)
- Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Freshney, N.W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J., Saklatvala, J. Cell (1994)
- Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. Cuesta, R., Laroia, G., Schneider, R.J. Genes Dev. (2000)
- Hsp27 negatively regulates cell death by interacting with cytochrome c. Bruey, J.M., Ducasse, C., Bonniaud, P., Ravagnan, L., Susin, S.A., Diaz-Latoud, C., Gurbuxani, S., Arrigo, A.P., Kroemer, G., Solary, E., Garrido, C. Nat. Cell Biol. (2000)
- Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells. Hansen, R.K., Parra, I., Lemieux, P., Oesterreich, S., Hilsenbeck, S.G., Fuqua, S.A. Breast Cancer Res. Treat. (1999)
- Change in the localization of heat shock protein 27 (HSP 27) in BG-1 human ovarian cancer cells following treatment by the ether lipid ET-18-OCH3. Fujiwara, K., Shirafuji, H., Fushitani, K., Fujimoto, K., Kohno, I., Modest, E.J. Anticancer Res. (1999)
- Hsp27 expression in neuroblastoma: correlation with disease stage. Ungar, D.R., Hailat, N., Strahler, J.R., Kuick, R.D., Brodeur, G.M., Seeger, R.C., Reynolds, C.P., Hanash, S.M. J. Natl. Cancer Inst. (1994)
- Estrogen receptors, progesterone receptors and heat-shock 27-kD protein in liver biopsy specimens from patients with hepatitis B virus infection. Ciocca, D.R., Jorge, A.D., Jorge, O., Milutín, C., Hosokawa, R., Díaz Lestren, M., Muzzio, E., Schulkin, S., Schirbu, R. Hepatology (1991)
- Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Chauhan, D., Li, G., Shringarpure, R., Podar, K., Ohtake, Y., Hideshima, T., Anderson, K.C. Cancer Res. (2003)
- Association of HSPB2, a member of the small heat shock protein family, with mitochondria. Nakagawa, M., Tsujimoto, N., Nakagawa, H., Iwaki, T., Fukumaki, Y., Iwaki, A. Exp. Cell Res. (2001)
- HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. Parcellier, A., Schmitt, E., Gurbuxani, S., Seigneurin-Berny, D., Pance, A., Chantôme, A., Plenchette, S., Khochbin, S., Solary, E., Garrido, C. Mol. Cell. Biol. (2003)
- Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation. Park, K.J., Gaynor, R.B., Kwak, Y.T. J. Biol. Chem. (2003)
- MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. Suzuki, A., Sugiyama, Y., Hayashi, Y., Nyu-i, N., Yoshida, M., Nonaka, I., Ishiura, S., Arahata, K., Ohno, S. J. Cell Biol. (1998)
- LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells. Ohnishi, K., Yasumoto, J., Takahashi, A., Ohnishi, T. Int. J. Oncol. (2006)
- Induction of HSP27 nuclear immunoreactivity during stress is modulated by vitamin C. Boxman, I.L., Kempenaar, J., de Haas, E., Ponec, M. Exp. Dermatol. (2002)
- Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes. Ito, H., Kamei, K., Iwamoto, I., Inaguma, Y., García-Mata, R., Sztul, E., Kato, K. J. Biochem. (2002)
- Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo. Navas, T.A., Nguyen, A.N., Hideshima, T., Reddy, M., Ma, J.Y., Haghnazari, E., Henson, M., Stebbins, E.G., Kerr, I., O'Young, G., Kapoun, A.M., Chakravarty, S., Mavunkel, B., Perumattam, J., Luedtke, G., Dugar, S., Medicherla, S., Protter, A.A., Schreiner, G.F., Anderson, K.C., Higgins, L.S. Leukemia (2006)
- p38 MAP kinase mediates platelet-derived growth factor-stimulated migration of hepatic myofibroblasts. Tangkijvanich, P., Santiskulvong, C., Melton, A.C., Rozengurt, E., Yee, H.F. J. Cell. Physiol. (2002)
- Phosphorylated HSP27 modulates the association of phosphorylated caldesmon with tropomyosin in colonic smooth muscle. Somara, S., Bitar, K.N. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. Sugiyama, Y., Suzuki, A., Kishikawa, M., Akutsu, R., Hirose, T., Waye, M.M., Tsui, S.K., Yoshida, S., Ohno, S. J. Biol. Chem. (2000)
- Transient up-regulation of myotonic dystrophy protein kinase-binding protein, MKBP, and HSP27 in the neonatal myocardium. Shama, K.M., Suzuki, A., Harada, K., Fujitani, N., Kimura, H., Ohno, S., Yoshida, K. Cell Struct. Funct. (1999)
- Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor kappa B of HeLa cells. Interference in signalling by the proteinase inhibitors 3,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone. Guesdon, F., Ikebe, T., Stylianou, E., Warwick-Davies, J., Haskill, S., Saklatvala, J. Biochem. J. (1995)
- Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3. Wen, F.C., Li, Y.H., Tsai, H.F., Lin, C.H., Li, C., Liu, C.S., Lii, C.K., Nukina, N., Hsieh, M. FEBS Lett. (2003)
- The small heat shock protein HSP27 is not an independent prognostic marker in axillary lymph node-negative breast cancer patients. Oesterreich, S., Hilsenbeck, S.G., Ciocca, D.R., Allred, D.C., Clark, G.M., Chamness, G.C., Osborne, C.K., Fuqua, S.A. Clin. Cancer Res. (1996)