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Gene Review

CLDN9  -  claudin 9

Homo sapiens

Synonyms: Claudin-9
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High impact information on CLDN9

  • In this junction, claudins partition into claudin-14 and claudin-9/6 subdomains that are distinguishable by strand morphology, which contrasts with in vitro data that most claudins co-assemble into heteromeric strands [1].
  • We also find that catenins colocalize with claudin-9 and claudin-6, but not claudin-14, in a heterologous system [1].
  • Surprisingly, canonical adherens junction proteins (p120ctn, alpha- and beta-catenins) colocalize with the claudin-9/6 subdomain and recruit a dense cytoskeletal network [1].


  1. Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. Nunes, F.D., Lopez, L.N., Lin, H.W., Davies, C., Azevedo, R.B., Gow, A., Kachar, B. J. Cell. Sci. (2006) [Pubmed]
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