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Gene Review

CLDN14  -  claudin 14

Homo sapiens

Synonyms: Claudin-14, UNQ777/PRO1571
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Psychiatry related information on CLDN14


High impact information on CLDN14


Biological context of CLDN14

  • We further identified hitherto undescribed exons of CLDN14 that are utilized in alternative spliced transcripts [5].
  • We determined an allelic loss of expression of the CLDN14 gene isoform at the 21q22.1 chromosomal breakpoint [1].
  • We previously reported that expression of claudin-14 in epithelial monolayers results in a fivefold increase in electrical resistance [4].

Anatomical context of CLDN14

  • To investigate this mechanism, we compared the ability of wild-type and missense mutant CLDN14 to form tight junctions [5].

Associations of CLDN14 with chemical compounds

  • Claudin-14, like other members of the claudin family, contains membrane-proximal cysteines following both the second and the fourth transmembrane domains, which we speculated could be modified by S-acylation with palmitic acid [4].

Other interactions of CLDN14


  1. tSNP-based identification of allelic loss of gene expression in a patient with a balanced chromosomal rearrangement. Guzauskas, G.F., Ukadike, K., Rimsky, L., Srivastava, A.K. Genomics (2007) [Pubmed]
  2. Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Wilcox, E.R., Burton, Q.L., Naz, S., Riazuddin, S., Smith, T.N., Ploplis, B., Belyantseva, I., Ben-Yosef, T., Liburd, N.A., Morell, R.J., Kachar, B., Wu, D.K., Griffith, A.J., Riazuddin, S., Friedman, T.B. Cell (2001) [Pubmed]
  3. Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. Nunes, F.D., Lopez, L.N., Lin, H.W., Davies, C., Azevedo, R.B., Gow, A., Kachar, B. J. Cell. Sci. (2006) [Pubmed]
  4. Palmitoylation of claudins is required for efficient tight-junction localization. Van Itallie, C.M., Gambling, T.M., Carson, J.L., Anderson, J.M. J. Cell. Sci. (2005) [Pubmed]
  5. Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. Wattenhofer, M., Reymond, A., Falciola, V., Charollais, A., Caille, D., Borel, C., Lyle, R., Estivill, X., Petersen, M.B., Meda, P., Antonarakis, S.E. Hum. Mutat. (2005) [Pubmed]
  6. Alterations in the GJB3 and CLDN14 genes in families with nonsyndromic sensorineural hearing loss. Arican, S.T., Incesulu, A., Inceoglu, B., Tekin, M. Genetic counseling (Geneva, Switzerland) (2005) [Pubmed]
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