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MeSH Review

Adherens Junctions

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Disease relevance of Adherens Junctions


High impact information on Adherens Junctions


Chemical compound and disease context of Adherens Junctions


Biological context of Adherens Junctions


Anatomical context of Adherens Junctions


Associations of Adherens Junctions with chemical compounds

  • Merlin colocalizes and interacts with adherens junction (AJ) components in confluent wild-type cells, suggesting that the lack of AJs and contact-dependent growth arrest in Nf2(-/-) cells directly results from the absence of merlin at sites of cell:cell contact [2].
  • Bazooka, a Par-3 homolog, is properly localized in the absence of adherens junctions, indicating that the formation of epithelial junctions is not the founding event of epithelial polarization [24].
  • The wild-type lck protein enhances CD4/MHC class II adhesion by augmenting the formation of CD4-associated adherens junctions whereas the elevated tyrosine kinase activity of the mutant p56lck decreases CD4-mediated cell adhesion by preventing the formation of these structures [25].
  • Phosphotyrosine has previously been found concentrated at adherens junctions, where bundles of actin filaments terminate, but video-enhanced contrast-differential interference contrast and confocal interference reflection microscopy demonstrated that the filopodial tips were not adherent to the substrate [26].
  • The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions [27].

Gene context of Adherens Junctions


Analytical, diagnostic and therapeutic context of Adherens Junctions


  1. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Matsumine, A., Ogai, A., Senda, T., Okumura, N., Satoh, K., Baeg, G.H., Kawahara, T., Kobayashi, S., Okada, M., Toyoshima, K., Akiyama, T. Science (1996) [Pubmed]
  2. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Lallemand, D., Curto, M., Saotome, I., Giovannini, M., McClatchey, A.I. Genes Dev. (2003) [Pubmed]
  3. Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Avizienyte, E., Wyke, A.W., Jones, R.J., McLean, G.W., Westhoff, M.A., Brunton, V.G., Frame, M.C. Nat. Cell Biol. (2002) [Pubmed]
  4. Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion. Chitaev, N.A., Troyanovsky, S.M. J. Cell Biol. (1997) [Pubmed]
  5. Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin. Wu, S., Lim, K.C., Huang, J., Saidi, R.F., Sears, C.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. p120-catenin mediates inflammatory responses in the skin. Perez-Moreno, M., Davis, M.A., Wong, E., Pasolli, H.A., Reynolds, A.B., Fuchs, E. Cell (2006) [Pubmed]
  7. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Yajnik, V., Paulding, C., Sordella, R., McClatchey, A.I., Saito, M., Wahrer, D.C., Reynolds, P., Bell, D.W., Lake, R., van den Heuvel, S., Settleman, J., Haber, D.A. Cell (2003) [Pubmed]
  8. The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Huber, A.H., Weis, W.I. Cell (2001) [Pubmed]
  9. Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. Hildebrand, J.D., Soriano, P. Cell (1999) [Pubmed]
  10. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Lee, M.J., Thangada, S., Claffey, K.P., Ancellin, N., Liu, C.H., Kluk, M., Volpi, M., Sha'afi, R.I., Hla, T. Cell (1999) [Pubmed]
  11. Regulation of adherens junction protein p120(ctn) by 10 nM CCK precedes actin breakdown in rat pancreatic acini. Leser, J., Beil, M.F., Musa, O.A., Adler, G., Lutz, M.P. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  12. Expression of desmoglein I and plakoglobin in skin carcinomas. Tada, H., Hatoko, M., Tanaka, A., Kuwahara, M., Muramatsu, T. J. Cutan. Pathol. (2000) [Pubmed]
  13. The effect of elevated extracellular glucose on adherens junction proteins in cultured rat heart endothelial cells. Lee, H.Z., Yeh, F.T., Wu, C.H. Life Sci. (2004) [Pubmed]
  14. Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions. Tsukita, S., Tsukita, S., Nagafuchi, A., Yonemura, S. Curr. Opin. Cell Biol. (1992) [Pubmed]
  15. Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. Tsukita, S., Oishi, K., Akiyama, T., Yamanashi, Y., Yamamoto, T., Tsukita, S. J. Cell Biol. (1991) [Pubmed]
  16. A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. Costa, M., Raich, W., Agbunag, C., Leung, B., Hardin, J., Priess, J.R. J. Cell Biol. (1998) [Pubmed]
  17. K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. Matsui, T., Kinoshita, T., Morikawa, Y., Tohya, K., Katsuki, M., Ito, Y., Kamiya, A., Miyajima, A. EMBO J. (2002) [Pubmed]
  18. CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. Eaton, S., Auvinen, P., Luo, L., Jan, Y.N., Simons, K. J. Cell Biol. (1995) [Pubmed]
  19. Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Guo, L., Degenstein, L., Dowling, J., Yu, Q.C., Wollmann, R., Perman, B., Fuchs, E. Cell (1995) [Pubmed]
  20. Cell contact- and shape-dependent regulation of vinculin synthesis in cultured fibroblasts. Ungar, F., Geiger, B., Ben-Ze'ev, A. Nature (1986) [Pubmed]
  21. F-actin binding site masked by the intramolecular association of vinculin head and tail domains. Johnson, R.P., Craig, S.W. Nature (1995) [Pubmed]
  22. Adenomatous polyposis coli proteins and cell adhesion. Bienz, M., Hamada, F. Curr. Opin. Cell Biol. (2004) [Pubmed]
  23. Cell-cell adhesion and signalling. Braga, V.M. Curr. Opin. Cell Biol. (2002) [Pubmed]
  24. E-cadherin-mediated adhesion is not the founding event of epithelial cell polarity in Drosophila. Le Bivic, A. Trends Cell Biol. (2005) [Pubmed]
  25. The protein tyrosine kinase p56lck regulates cell adhesion mediated by CD4 and major histocompatibility complex class II proteins. Kinch, M.S., Sanfridson, A., Doyle, C. J. Exp. Med. (1994) [Pubmed]
  26. Regulated tyrosine phosphorylation at the tips of growth cone filopodia. Wu, D.Y., Goldberg, D.J. J. Cell Biol. (1993) [Pubmed]
  27. The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. Fialka, I., Schwarz, H., Reichmann, E., Oft, M., Busslinger, M., Beug, H. J. Cell Biol. (1996) [Pubmed]
  28. The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Nagafuchi, A., Takeichi, M., Tsukita, S. Cell (1991) [Pubmed]
  29. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Bilder, D., Perrimon, N. Nature (2000) [Pubmed]
  30. shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia. Tepass, U., Gruszynski-DeFeo, E., Haag, T.A., Omatyar, L., Török, T., Hartenstein, V. Genes Dev. (1996) [Pubmed]
  31. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Georgakopoulos, A., Marambaud, P., Efthimiopoulos, S., Shioi, J., Cui, W., Li, H.C., Schütte, M., Gordon, R., Holstein, G.R., Martinelli, G., Mehta, P., Friedrich, V.L., Robakis, N.K. Mol. Cell (1999) [Pubmed]
  32. Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Tanentzapf, G., Tepass, U. Nat. Cell Biol. (2003) [Pubmed]
  33. Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila. Zarnescu, D.C., Thomas, G.H. J. Cell Biol. (1999) [Pubmed]
  34. Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions. Del Maschio, A., Zanetti, A., Corada, M., Rival, Y., Ruco, L., Lampugnani, M.G., Dejana, E. J. Cell Biol. (1996) [Pubmed]
  35. Phosphatidylinositol 3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation. Laprise, P., Chailler, P., Houde, M., Beaulieu, J.F., Boucher, M.J., Rivard, N. J. Biol. Chem. (2002) [Pubmed]
  36. JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. Ohnishi, H., Nakahara, T., Furuse, K., Sasaki, H., Tsukita, S., Furuse, M. J. Biol. Chem. (2004) [Pubmed]
  37. Requirement for Ras and phosphatidylinositol 3-kinase signaling uncouples the glucocorticoid-induced junctional organization and transepithelial electrical resistance in mammary tumor cells. Woo, P.L., Ching, D., Guan, Y., Firestone, G.L. J. Biol. Chem. (1999) [Pubmed]
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