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Gene Review

TMSB4Y  -  thymosin beta 4, Y-linked

Homo sapiens

Synonyms: TB4Y, Thymosin beta-4, Y-chromosomal
 
 
 
 
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High impact information on TMSB4Y

  • All previously identified H-Y Ags are encoded by conventional open reading frames, but we report in this study the identification of a novel H-Y Ag encoded in the 5'-untranslated region of the TMSB4Y gene [1].
  • A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene [1].
  • Tetramer analysis continued to detect TMSB4Y/A33-specific CD8(+) T cells at least up to 700 days post-HSCT [1].
  • Minigene transfection and epitope reconstitution assays identified an 11-mer peptide, EVLLRPGLHFR, designated TMSB4Y/A33, whose first amino acid was located 405 bp upstream of the TMSB4Y initiation codon [1].
 

Anatomical context of TMSB4Y

  • Analysis of the precursor frequency of CTL specific for recipient minor histocompatibility Ags in post-HSCT peripheral blood T cells revealed that a significant fraction of the total donor CTL response in this patient was directed against the TMSB4Y epitope [1].

References

  1. A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. Torikai, H., Akatsuka, Y., Miyazaki, M., Warren, E.H., Oba, T., Tsujimura, K., Motoyoshi, K., Morishima, Y., Kodera, Y., Kuzushima, K., Takahashi, T. J. Immunol. (2004) [Pubmed]
 
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