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Gene Review

KDM5D  -  lysine (K)-specific demethylase 5D

Homo sapiens

Synonyms: H-Y, HY, HYA, Histocompatibility Y antigen, Histone demethylase JARID1D, ...
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Disease relevance of JARID1D


Psychiatry related information on JARID1D


High impact information on JARID1D


Chemical compound and disease context of JARID1D


Biological context of JARID1D


Anatomical context of JARID1D

  • Moreover, all cytotoxic T lymphocytes tested (n=6) were specific for the SMCY-derived peptide FIDSYICQV, originally described as being the H-Y epitope recognized in the context of HLA-A*0201 [13].
  • H-Y antigen has been defined by various immunological methods including graft rejection, T-cell mediated cytolysis, and antiserum cytotoxicity [11].
  • Anti-H-Y antisera detect a membrane bound antigen associated with beta2-microglobulin, and a soluble protein secreted by testicular Sertoli cells [11].
  • H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus [14].
  • In contrast to the SMCY-encoded H-Y epitopes, the B8/H-Y Ag was not presented by fibroblasts from male donors, suggesting that it was encoded by a novel gene [15].

Associations of JARID1D with chemical compounds

  • Cutting edge: the HLA-A*0101-restricted HY minor histocompatibility antigen originates from DFFRY and contains a cysteinylated cysteine residue as identified by a novel mass spectrometric technique [16].
  • Although arginine at position 2 is a dominant anchor residue for peptides bound to B27, neither B27-presented HY sequence contains this residue [17].
  • In non-mammalian vertebrates, H-Y antigen is controlled by other factors, e.g. steroid hormones [18].
  • The increase in the thickness of the epidermal HYA meshwork after 6 months and the blister fluid HYA after 2 weeks may indicate that HYA is involved in the epidermal change induced by topical retinoic acid therapy.(ABSTRACT TRUNCATED AT 250 WORDS)[19]
  • This study was undertaken with the aim of localizing hyaluronan (hyaluronic acid, HYA) in tissue sections of the human endolymphatic sac by use of a hyaluronan-binding affinity protein and the avidin-biotin/peroxidase staining procedure [20].

Regulatory relationships of JARID1D

  • The human homologues SMCY and UTY likewise express HY antigens and these are targets of damaging graft-versus-host (GVH) responses and potentially therapeutic graft-versus-leukaemia (GVL) responses following bone marrow transplantation (BMT) [21].

Other interactions of JARID1D

  • Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven [22].
  • The UTY-derived H-Y antigen was characterized as a 10-amino acid residue peptide, RESEEESVSL [23].
  • All previously identified H-Y Ags are encoded by conventional open reading frames, but we report in this study the identification of a novel H-Y Ag encoded in the 5'-untranslated region of the TMSB4Y gene [24].
  • Although the epitope differed by 3 amino acids from its X-homologue, UTX, only 2 polymorphisms were essential for recognition by the CTL clone HLA-B60 HY [23].
  • However, A1-HY-specific CTL recognize the DFFRY-derived peptide at a 1500-fold lower dose than the female homologue [16].

Analytical, diagnostic and therapeutic context of JARID1D


  1. Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission. Miklos, D.B., Kim, H.T., Miller, K.H., Guo, L., Zorn, E., Lee, S.J., Hochberg, E.P., Wu, C.J., Alyea, E.P., Cutler, C., Ho, V., Soiffer, R.J., Antin, J.H., Ritz, J. Blood (2005) [Pubmed]
  2. Minor Histocompatibility Antigen DDX3Y Induces HLA-DQ5-Restricted T Cell Responses with Limited TCR-Vbeta Usage Both In Vivo and In Vitro. Laurin, D., Spierings, E., van der Veken, L.T., Hamrouni, A., Falkenburg, J.H., Souillet, G., Vermeulen, C., Farre, A., Galambrun, C., Rigal, D., Bertrand, Y., Goulmy, E., Eljaafari, A. Biol. Blood Marrow Transplant. (2006) [Pubmed]
  3. Sex mismatch as a risk factor for chronic rejection of liver allografts. Candinas, D., Gunson, B.K., Nightingale, P., Hubscher, S., McMaster, P., Neuberger, J.M. Lancet (1995) [Pubmed]
  4. Mannose-binding lectin-2 genetic variation and stomach cancer risk. Baccarelli, A., Hou, L., Chen, J., Lissowska, J., El-Omar, E.M., Grillo, P., Giacomini, S.M., Yaeger, M., Bernig, T., Zatonski, W., Fraumeni, J.F., Chanock, S.J., Chow, W.H. Int. J. Cancer (2006) [Pubmed]
  5. H-Y antigen in transsexuality, and how to explain testis differentiation in H-Y antigen-negative males and ovary differentiation in H-Y antigen-positive females. Engel, W., Pfäfflin, F., Wiedeking, C. Hum. Genet. (1980) [Pubmed]
  6. The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning. Simpson, E., Scott, D., Chandler, P. Annu. Rev. Immunol. (1997) [Pubmed]
  7. Testis-determining H-Y antigen in XO males of the mole-vole (Ellobius lutescens). Nagai, Y., Ohno, S. Cell (1977) [Pubmed]
  8. Seven different assays of hyaluronan compared for clinical utility. Lindqvist, U., Chichibu, K., Delpech, B., Goldberg, R.L., Knudson, W., Poole, A.R., Laurent, T.C. Clin. Chem. (1992) [Pubmed]
  9. Population genetic implications from sequence variation in four Y chromosome genes. Shen, P., Wang, F., Underhill, P.A., Franco, C., Yang, W.H., Roxas, A., Sung, R., Lin, A.A., Hyman, R.W., Vollrath, D., Davis, R.W., Cavalli-Sforza, L.L., Oefner, P.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  10. DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection. Vogt, M.H., de Paus, R.A., Voogt, P.J., Willemze, R., Falkenburg, J.H. Blood (2000) [Pubmed]
  11. The serologically detected H-Y antigen revisited. Wolf, U. Cytogenet. Cell Genet. (1998) [Pubmed]
  12. Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping. Murphy, W.J., Sun, S., Chen, Z.Q., Pecon-Slattery, J., O'Brien, S.J. Genome Res. (1999) [Pubmed]
  13. HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation. Rufer, N., Wolpert, E., Helg, C., Tiercy, J.M., Gratwohl, A., Chapuis, B., Jeannet, M., Goulmy, E., Roosnek, E. Transplantation (1998) [Pubmed]
  14. Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. Wang, W., Meadows, L.R., den Haan, J.M., Sherman, N.E., Chen, Y., Blokland, E., Shabanowitz, J., Agulnik, A.I., Hendrickson, R.C., Bishop, C.E. Science (1995) [Pubmed]
  15. The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen. Warren, E.H., Gavin, M.A., Simpson, E., Chandler, P., Page, D.C., Disteche, C., Stankey, K.A., Greenberg, P.D., Riddell, S.R. J. Immunol. (2000) [Pubmed]
  16. Cutting edge: the HLA-A*0101-restricted HY minor histocompatibility antigen originates from DFFRY and contains a cysteinylated cysteine residue as identified by a novel mass spectrometric technique. Pierce, R.A., Field, E.D., den Haan, J.M., Caldwell, J.A., White, F.M., Marto, J.A., Wang, W., Frost, L.M., Blokland, E., Reinhardus, C., Shabanowitz, J., Hunt, D.F., Goulmy, E., Engelhard, V.H. J. Immunol. (1999) [Pubmed]
  17. Novel HY peptide antigens presented by HLA-B27. Simmons, W.A., Summerfield, S.G., Roopenian, D.C., Slaughter, C.A., Zuberi, A.R., Gaskell, S.J., Bordoli, R.S., Hoyes, J., Moomaw, C.R., Colbert, R.A., Leong, L.Y., Butcher, G.W., Hammer, R.E., Taurog, J.D. J. Immunol. (1997) [Pubmed]
  18. Genetic aspects of H-Y antigen. Wolf, U. Hum. Genet. (1981) [Pubmed]
  19. Topical retinoic acid treatment of photoaged skin: its effects on hyaluronan distribution in epidermis and on hyaluronan and retinoic acid in suction blister fluid. Lundin, A., Berne, B., Michaëlsson, G. Acta Derm. Venereol. (1992) [Pubmed]
  20. Localization of hyaluronan in the human endolymphatic sac. A study using the affinity hyaluronan binding protein. Danckwardt-Lillieström, N., Laurent, C., Hellström, S., Friberg, U., Kinnefors, A., Rask-Andersen, H. Acta Otolaryngol. (1994) [Pubmed]
  21. The case of the midwife scientist. Simpson, E. Int. J. Dev. Biol. (2001) [Pubmed]
  22. Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven. Agulnik, A.I., Bishop, C.E., Lerner, J.L., Agulnik, S.I., Solovyev, V.V. Mamm. Genome (1997) [Pubmed]
  23. UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition. Vogt, M.H., Goulmy, E., Kloosterboer, F.M., Blokland, E., de Paus, R.A., Willemze, R., Falkenburg, J.H. Blood (2000) [Pubmed]
  24. A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. Torikai, H., Akatsuka, Y., Miyazaki, M., Warren, E.H., Oba, T., Tsujimura, K., Motoyoshi, K., Morishima, Y., Kodera, Y., Kuzushima, K., Takahashi, T. J. Immunol. (2004) [Pubmed]
  25. Role of antiserum and complement in the acute antibody-mediated rejection of mouse skin allografts in strain combinations with increasing histoincompatibility. Berden, J.H., Gerlag, P.G., Hagemann, J.F., Koene, R.A. Transplantation (1977) [Pubmed]
  26. Isolation of an HLA-A2.1 extracted human minor histocompatibility peptide. de Bueger, M., Verreck, F., Blokland, E., Drijfhout, J.W., Amons, R., Koning, F., Goulmy, E. Eur. J. Immunol. (1993) [Pubmed]
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