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Disease relevance of Histocompatibility


Psychiatry related information on Histocompatibility

  • BsAb were directed against immunoglobulin-idiotype (Id), major histocompatibility class II (MHC II), or CD19 on the tumors and huCD64 on the effectors [6].

High impact information on Histocompatibility

  • Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus [7]?
  • Although there is evidence that the development of MS is determined by both environmental influences and genes, these factors are largely undefined, except for major histocompatibility (MHC) genes [8].
  • CYP21B is located in the HLA histocompatibility complex, and a "nonclassic" allelic variant is often associated with characteristic HLA antigens--B14,DR1 [9].
  • Evidence for specific association between class I major histocompatibility antigens and the CD8 molecules of human suppressor/cytotoxic cells [10].
  • To study the association of histocompatibility (HLA) genes in black persons with juvenile-onset diabetes, we determined HLA-A, HLA-B, HLA-C and HLA-DR specificities in 40 black Americans with this disease and in 67 unaffected black Americans [11].

Chemical compound and disease context of Histocompatibility


Biological context of Histocompatibility


Anatomical context of Histocompatibility


Associations of Histocompatibility with chemical compounds

  • We have determined the structure of a second human histocompatibility glycoprotein, HLA-Aw68, by X-ray crystallography and refined it to a resolution of 2.6 A [27].
  • The rat MHC class Ia molecule RT1-Aa has the unusual capacity to bind long peptides ending in arginine, such as MTF-E, a thirteen-residue, maternally transmitted minor histocompatibility antigen [28].
  • In human histocompatibility leukocyte antigen (HLA)-B57+ HIV-infected persons, immune selection pressure leads to a mutation from alanine to proline at Gag residue 146 immediately preceding the NH2 terminus of a dominant HLA-B57-restricted epitope, ISPRTLNAW [29].
  • We conclude that short, allergen-derived peptides can directly initiate a major histocompatibility complex-restricted, T cell-dependent late asthmatic reaction, without the requirement for an early IgE/mast cell-dependent response, in sensitized asthmatic subjects [30].
  • Complement-human histocompatibility antigen haplotypes in C2 deficiency [31].

Gene context of Histocompatibility


Analytical, diagnostic and therapeutic context of Histocompatibility


  1. An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens. Burgert, H.G., Kvist, S. Cell (1985) [Pubmed]
  2. Sjögren's syndrome association with HLA-Dw3. Chused, T.M., Kassan, S.S., Opelz, G., Moutsopoulos, H.M., Terasaki, P.I. N. Engl. J. Med. (1977) [Pubmed]
  3. The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide. Stern, L.J., Wiley, D.C. Cell (1992) [Pubmed]
  4. Atomic structure of a human MHC molecule presenting an influenza virus peptide. Silver, M.L., Guo, H.C., Strominger, J.L., Wiley, D.C. Nature (1992) [Pubmed]
  5. Human CD4 binds immunoglobulins. Lenert, P., Kroon, D., Spiegelberg, H., Golub, E.S., Zanetti, M. Science (1990) [Pubmed]
  6. Therapeutic efficacy of FcgammaRI/CD64-directed bispecific antibodies in B-cell lymphoma. Honeychurch, J., Tutt, A.L., Valerius, T., Heijnen, I.A., Van De Winkel, J.G., Glennie, M.J. Blood (2000) [Pubmed]
  7. Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus? Vorechovsky, I., Kralovicova, J., Tchilian, E., Masterman, T., Zhang, Z., Ferry, B., Misbah, S., Chapel, H., Webster, D., Hellgren, D., Anvret, M., Hillert, J., Hammarstrom, L., Beverley, P.C. Nat. Genet. (2001) [Pubmed]
  8. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Madsen, L.S., Andersson, E.C., Jansson, L., krogsgaard, M., Andersen, C.B., Engberg, J., Strominger, J.L., Svejgaard, A., Hjorth, J.P., Holmdahl, R., Wucherpfennig, K.W., Fugger, L. Nat. Genet. (1999) [Pubmed]
  9. Molecular genetic analysis of nonclassic steroid 21-hydroxylase deficiency associated with HLA-B14,DR1. Speiser, P.W., New, M.I., White, P.C. N. Engl. J. Med. (1988) [Pubmed]
  10. Evidence for specific association between class I major histocompatibility antigens and the CD8 molecules of human suppressor/cytotoxic cells. Blue, M.L., Craig, K.A., Anderson, P., Branton, K.R., Schlossman, S.F. Cell (1988) [Pubmed]
  11. HLA-DR specificities among black Americans with juvenile-onset diabetes. Rodey, G.E., White, N., Frazer, T.E., Duquesnoy, R.J., Santiago, J.V. N. Engl. J. Med. (1979) [Pubmed]
  12. Importance of peptide amino and carboxyl termini to the stability of MHC class I molecules. Bouvier, M., Wiley, D.C. Science (1994) [Pubmed]
  13. Expression of epithelial-like markers and class I major histocompatibility antigens by a murine carcinoma growing in the mammary gland and in metastases: orthotopic site effects. Elliott, B.E., Maxwell, L., Arnold, M., Wei, W.Z., Miller, F.R. Cancer Res. (1988) [Pubmed]
  14. Vertebral ankylosing hyperostosis (Forestier's disease) and HLA antigens in Pima Indians. Spagnola, A.M., Bennett, P.H., Terasaki, P.I. Arthritis Rheum. (1978) [Pubmed]
  15. Immunoglobulin allotypes in families with pauciarticular-onset juvenile chronic arthritis. Hall, P.J., de Lange, G.G., Ansell, B.M. Tissue Antigens (1985) [Pubmed]
  16. Increased frequency of complement C4 'null' alleles in recurrent spontaneous abortions. Laitinen, T., Lokki, M.L., Tulppala, M., Ylikorkala, O., Koskimies, S. Hum. Reprod. (1991) [Pubmed]
  17. Linkage between the gene (or genes) controlling synthesis of the fourth component of complement and the major histocompatibility complex. Ochs, H.D., Rosenfeld, S.I., Thomas, E.D., Giblett, E.R., Alper, C.A., Dupont, B., Schaller, J.G., Gilliland, B.C., Hansen, J.A., Wedgwood, R.J. N. Engl. J. Med. (1977) [Pubmed]
  18. Correlation between a DNA restriction fragment length polymorphism and C4A6 protein. Palsdottir, A., Cross, S.J., Edwards, J.H., Carroll, M.C. Nature (1983) [Pubmed]
  19. Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. Auffray, C., Lillie, J.W., Arnot, D., Grossberger, D., Kappes, D., Strominger, J.L. Nature (1984) [Pubmed]
  20. Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Tarleton, R.L., Koller, B.H., Latour, A., Postan, M. Nature (1992) [Pubmed]
  21. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Gong, J., Chen, D., Kashiwaba, M., Kufe, D. Nat. Med. (1997) [Pubmed]
  22. Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Albani, S., Keystone, E.C., Nelson, J.L., Ollier, W.E., La Cava, A., Montemayor, A.C., Weber, D.A., Montecucco, C., Martini, A., Carson, D.A. Nat. Med. (1995) [Pubmed]
  23. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J.C., Montagnier, L. Nature (1984) [Pubmed]
  24. Differential clustering of CD4 and CD3zeta during T cell recognition. Krummel, M.F., Sjaastad, M.D., Wülfing, C., Davis, M.M. Science (2000) [Pubmed]
  25. An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo. Yagüe, J., Alvarez, I., Rognan, D., Ramos, M., Vázquez, J., de Castro, J.A. J. Exp. Med. (2000) [Pubmed]
  26. Major histocompatibility complex-restricted H-Y-specific antibodies and cytotoxic T lymphocytes may recognize different self determinants. Goulmy, E., van Leeuwen, A., Blokland, E., van Rood, J.J., Biddison, W.E. J. Exp. Med. (1982) [Pubmed]
  27. Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Garrett, T.P., Saper, M.A., Bjorkman, P.J., Strominger, J.L., Wiley, D.C. Nature (1989) [Pubmed]
  28. Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa. Speir, J.A., Stevens, J., Joly, E., Butcher, G.W., Wilson, I.A. Immunity (2001) [Pubmed]
  29. Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. Draenert, R., Le Gall, S., Pfafferott, K.J., Leslie, A.J., Chetty, P., Brander, C., Holmes, E.C., Chang, S.C., Feeney, M.E., Addo, M.M., Ruiz, L., Ramduth, D., Jeena, P., Altfeld, M., Thomas, S., Tang, Y., Verrill, C.L., Dixon, C., Prado, J.G., Kiepiela, P., Martinez-Picado, J., Walker, B.D., Goulder, P.J. J. Exp. Med. (2004) [Pubmed]
  30. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. Haselden, B.M., Kay, A.B., Larché, M. J. Exp. Med. (1999) [Pubmed]
  31. Complement-human histocompatibility antigen haplotypes in C2 deficiency. Awdeh, Z.L., Raum, D.D., Glass, D., Agnello, V., Schur, P.H., Johnston, R.B., Gelfand, E.W., Ballow, M., Yunis, E., Alper, C.A. J. Clin. Invest. (1981) [Pubmed]
  32. Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway. Krangel, M.S. J. Exp. Med. (1986) [Pubmed]
  33. Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. Yeung, R.S., Penninger, J.M., Kündig, T.M., Law, Y., Yamamoto, K., Kamikawaji, N., Burkly, L., Sasazuki, T., Flavell, R., Ohashi, P.S., Mak, T.W. J. Exp. Med. (1994) [Pubmed]
  34. Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. Akatsuka, Y., Nishida, T., Kondo, E., Miyazaki, M., Taji, H., Iida, H., Tsujimura, K., Yazaki, M., Naoe, T., Morishima, Y., Kodera, Y., Kuzushima, K., Takahashi, T. J. Exp. Med. (2003) [Pubmed]
  35. Generation of lymphokine-activated killer cells: synergy between tumor necrosis factor and interleukin 2. Chouaib, S., Bertoglio, J., Blay, J.Y., Marchiol-Fournigault, C., Fradelizi, D. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  36. Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Okamoto, K., Makino, S., Yoshikawa, Y., Takaki, A., Nagatsuka, Y., Ota, M., Tamiya, G., Kimura, A., Bahram, S., Inoko, H. Am. J. Hum. Genet. (2003) [Pubmed]
  37. Renal transplantation update. Fine, R.N., Terasaki, P.I., Ettenger, R.B., Danovitch, G., Ehrlich, R.M. Ann. Intern. Med. (1984) [Pubmed]
  38. Vascular cell adhesion molecule-1 is induced on vascular endothelia and medial smooth muscle cells in experimental cardiac allograft vasculopathy. Ardehali, A., Laks, H., Drinkwater, D.C., Ziv, E., Drake, T.A. Circulation (1995) [Pubmed]
  39. Identification of human genomic clones coding the major histocompatibility antigens HLA-a2 and HLA-B7 by DNA-mediated gene transfer. Barbosa, J.A., Kamarck, M.E., Biro, P.A., Weissman, S.M., Ruddle, F.H. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  40. Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen-specific cytotoxic T lymphocytes. Oosten, L.E., Blokland, E., van Halteren, A.G., Curtsinger, J., Mescher, M.F., Falkenburg, J.H., Mutis, T., Goulmy, E. Blood (2004) [Pubmed]
  41. Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia. Kloosterboer, F.M., van Luxemburg-Heijs, S.A., van Soest, R.A., van Egmond, H.M., Willemze, R., Falkenburg, J.H. Blood (2005) [Pubmed]
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