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Gene Review

CERS5  -  ceramide synthase 5

Homo sapiens

Synonyms: CerS5, Ceramide synthase 5, FLJ25304, LAG1 longevity assurance homolog 5, LASS5, ...
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High impact information on LASS5


Analytical, diagnostic and therapeutic context of LASS5

  • After elution from agarose beads, only one band could be detected by SDS-PAGE, and its identity was confirmed to be LASS5 by mass spectrometry [1].
  • To determine whether LASS5 is a bona fide dihydroceramide synthase or, alternatively, whether it modifies an endogenous dihydroceramide synthase, we over-expressed LASS5 with a hemagglutinin (HA) tag at the C terminus, solubilized it using digitonin, and purified it by immunoprecipitation [1].


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