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Chemical Compound Review

P9804_SIGMA     [5-(6-aminopurin-9-yl)-2- [[[[3-[2-(2...

Synonyms: AR-1L3794, AC1L1AH5, AC1Q68ZG, Hexadecanoyl-CoA, Palmitoyl-(carbonyl-14C)-coenzyme A
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Disease relevance of palmitoyl coenzyme A


Psychiatry related information on palmitoyl coenzyme A


High impact information on palmitoyl coenzyme A


Chemical compound and disease context of palmitoyl coenzyme A


Biological context of palmitoyl coenzyme A


Anatomical context of palmitoyl coenzyme A


Associations of palmitoyl coenzyme A with other chemical compounds


Gene context of palmitoyl coenzyme A


Analytical, diagnostic and therapeutic context of palmitoyl coenzyme A

  • When the palmitoyl-CoA containing inactive subunits were isolated by gel filtration on Sepharose 6B, and then concentrated and dialyzed against 0.5 M phosphate buffer, pH 7.0, containing 3 mM of the complexing agent heptakis-(2,6-di-O-methyl)-beta-cyclodextrin, activity was regenerated to the level of 40 percent of a control sample [2].
  • Finally, titrations of bSULT1A1-pentachlorophenol complex with palmitoyl-CoA caused the return of protein fluorescence, and the binding of palmitoyl-CoA was highly cooperative (Hill constant of 1.9) [34].
  • We use excised patch-clamp techniques to assess the effects of N- and C-terminal Kir6.2 mutations on the activation of recombinant K(ATP) channels by palmitoyl CoA [35].
  • Upon differential centrifugation, the subcellular distribution of ciprofibroyl-CoA synthetase followed closely that of palmitoyl-CoA synthetase and was specifically inactivated in the mitochondrial fraction by freezing and thawing, a behaviour already described for palmitoyl-CoA synthetase [36].
  • Second, incubation of GAPDH with [(14)C]palmitoyl-CoA followed by SDS-PAGE and autoradiography identified a covalently radiolabeled adduct present at approximately 35 kDa with a stoichiometry of one molecule of palmitoyl-CoA per GAPDH tetramer [37].


  1. Use of Escherichia coli strains containing fad mutations plus a triple plasmid expression system to study the import of myristate, its activation by Saccharomyces cerevisiae acyl-CoA synthetase, and its utilization by S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Knoll, L.J., Gordon, J.I. J. Biol. Chem. (1993) [Pubmed]
  2. Reversible inhibition of the fatty acid synthetase complex from Mycobacterium smegmatis by palmitoyl-coenzyme A. Flick, P.K., Bloch, K. J. Biol. Chem. (1975) [Pubmed]
  3. Modular kinetic analysis of the adenine nucleotide translocator-mediated effects of palmitoyl-CoA on the oxidative phosphorylation in isolated rat liver mitochondria. Ciapaite, J., Van Eikenhorst, G., Bakker, S.J., Diamant, M., Heine, R.J., Wagner, M.J., Westerhoff, H.V., Krab, K. Diabetes (2005) [Pubmed]
  4. Hepatic peroxisomal and mitochondrial fatty acid oxidation in the riboflavin-deficient rat. Brady, P.S., Hoppel, C.L. Biochem. J. (1985) [Pubmed]
  5. Effect of thyroidectomy on the kinetics of ADP-ATP translocation in liver mitochondria. Mak, I.T., Shrago, E., Elson, C.E. Arch. Biochem. Biophys. (1983) [Pubmed]
  6. Decrease of palmitoyl-CoA elongation in platelets and leukocytes in the patient of hereditary methemoglobinemia associated with mental retardation. Takeshita, M., Tamura, M., Kugi, M., Matsuki, T., Yoneyama, Y., Igarashi, T. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  7. Partial muscle carnitine palmitoyltransferase-A deficiency. Rhabdomyolysis associated with transiently decreased muscle carnitine content after ibuprofen therapy. Ross, N.S., Hoppel, C.L. JAMA (1987) [Pubmed]
  8. Increased hepatic mitochondrial capacity in rats with hydroxy-cobalamin[c-lactam]-induced methylmalonic aciduria. Krahenbuhl, S., Ray, D.B., Stabler, S.P., Allen, R.H., Brass, E.P. J. Clin. Invest. (1990) [Pubmed]
  9. Hepatotoxicity of vitamin A and ethanol in the rat. Leo, M.A., Arai, M., Sato, M., Lieber, C.S. Gastroenterology (1982) [Pubmed]
  10. A role for BARS at the fission step of COPI vesicle formation from Golgi membrane. Yang, J.S., Lee, S.Y., Spanò, S., Gad, H., Zhang, L., Nie, Z., Bonazzi, M., Corda, D., Luini, A., Hsu, V.W. EMBO J. (2005) [Pubmed]
  11. The production of post-Golgi vesicles requires a protein kinase C-like molecule, but not its phosphorylating activity. Simon, J.P., Ivanov, I.E., Adesnik, M., Sabatini, D.D. J. Cell Biol. (1996) [Pubmed]
  12. Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Palmitoyl-CoA inhibition of the biosynthetic sn-glycerol-3-phosphate dehydrogenase. Edgar, J.R., Bell, R.M. J. Biol. Chem. (1979) [Pubmed]
  13. Mycobacterium smegmatis fatty acid synthetase. Polysaccharide stimulation of the rate-limiting step. Banis, R.J., Peterson, D.O., Bloch, K. J. Biol. Chem. (1977) [Pubmed]
  14. Purification and properties of acyl coenzyme A thioesterase II from Rhodopseudomonas sphaeroides. Seay, T., Lueking, D.R. Biochemistry (1986) [Pubmed]
  15. Hepatic mitochondrial and peroxisomal oxidative capacity in riboflavin deficiency: effect of age, dietary fat and starvation in rats. Brady, P.S., Knoeber, C.M., Brady, L.J. J. Nutr. (1986) [Pubmed]
  16. Identification of acyl donors and acceptor proteins for fatty acid acylation in BHK cells infected with Semliki Forest virus. Berger, M., Schmidt, M.F. EMBO J. (1984) [Pubmed]
  17. Effect of polymethylpolysaccharides on the hydrolysis of palmitoyl coenzyme A by a thioesterase from Mycobacterium smegmatis. Yabusaki, K.K., Ballou, C.E. J. Biol. Chem. (1979) [Pubmed]
  18. Functional deacylases of pigeon liver fatty acid synthetase complex. Kumar, S. J. Biol. Chem. (1975) [Pubmed]
  19. Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors. Declercq, P.E., Falck, J.R., Kuwajima, M., Tyminski, H., Foster, D.W., McGarry, J.D. J. Biol. Chem. (1987) [Pubmed]
  20. Biochemical effects and zonal heterogeneity of peroxisome proliferation induced by perfluorocarboxylic acids in rat liver. Just, W.W., Gorgas, K., Hartl, F.U., Heinemann, P., Salzer, M., Schimassek, H. Hepatology (1989) [Pubmed]
  21. Very long chain acyl-coenzyme A dehydrogenase deficiency with adult onset. Smelt, A.H., Poorthuis, B.J., Onkenhout, W., Scholte, H.R., Andresen, B.S., van Duinen, S.G., Gregersen, N., Wintzen, A.R. Ann. Neurol. (1998) [Pubmed]
  22. Role of the surface excess of palmitoyl coenzyme A in the 1-acylglycerol-3-phosphate acyltransferase reaction catalyzed by microsomes. Brockman, H.L. J. Biol. Chem. (1975) [Pubmed]
  23. Export of mitochondrially synthesized lysophosphatidic acid. Haldar, D., Lipfert, L. J. Biol. Chem. (1990) [Pubmed]
  24. Distinct kinetics of carnitine palmitoyltransferase i in contact sites and outer membranes of rat liver mitochondria. Fraser, F., Padovese, R., Zammit, V.A. J. Biol. Chem. (2001) [Pubmed]
  25. Role of reversible phosphorylation of acetyl-CoA carboxylase in long-chain fatty acid synthesis. Kim, K.H., López-Casillas, F., Bai, D.H., Luo, X., Pape, M.E. FASEB J. (1989) [Pubmed]
  26. The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase. Cook, G.A. J. Biol. Chem. (1987) [Pubmed]
  27. Evidence for multiple condensing enzymes in rat hepatic microsomes catalyzing the condensation of saturated, monounsaturated, and polyunsaturated acyl coenzyme A. Prasad, M.R., Nagi, M.N., Ghesquier, D., Cook, L., Cinti, D.L. J. Biol. Chem. (1986) [Pubmed]
  28. Rat liver peroxisomes catalyze the beta oxidation of fatty acids. Lazarow, P.B. J. Biol. Chem. (1978) [Pubmed]
  29. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. Miyazaki, M., Dobrzyn, A., Sampath, H., Lee, S.H., Man, W.C., Chu, K., Peters, J.M., Gonzalez, F.J., Ntambi, J.M. J. Biol. Chem. (2004) [Pubmed]
  30. Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. Hanada, K., Hara, T., Nishijima, M. J. Biol. Chem. (2000) [Pubmed]
  31. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2. Calero, G., Gupta, P., Nonato, M.C., Tandel, S., Biehl, E.R., Hofmann, S.L., Clardy, J. J. Biol. Chem. (2003) [Pubmed]
  32. Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes? Riedel, M.J., Boora, P., Steckley, D., de Vries, G., Light, P.E. Diabetes (2003) [Pubmed]
  33. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. Lahiri, S., Futerman, A.H. J. Biol. Chem. (2005) [Pubmed]
  34. Inhibition of bovine phenol sulfotransferase (bSULT1A1) by CoA thioesters. Evidence for positive cooperativity and inhibition by interaction with both the nucleotide and phenol binding sites. Tulik, G.R., Chodavarapu, S., Edgar, R., Giannunzio, L., Langland, A., Schultz, B., Beckmann, J.D. J. Biol. Chem. (2002) [Pubmed]
  35. Activation of adenosine triphosphate-sensitive potassium channels by acyl coenzyme A esters involves multiple phosphatidylinositol 4,5-bisphosphate-interacting residues. Manning Fox, J.E., Nichols, C.G., Light, P.E. Mol. Endocrinol. (2004) [Pubmed]
  36. Subcellular distribution and characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase. Amigo, L., McElroy, M.C., Morales, M.N., Bronfman, M. Biochem. J. (1992) [Pubmed]
  37. Submicromolar concentrations of palmitoyl-CoA specifically thioesterify cysteine 244 in glyceraldehyde-3-phosphate dehydrogenase inhibiting enzyme activity: a novel mechanism potentially underlying fatty acid induced insulin resistance. Yang, J., Gibson, B., Snider, J., Jenkins, C.M., Han, X., Gross, R.W. Biochemistry (2005) [Pubmed]
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