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Gene Review:

WNVgp1 - polyprotein precursor

West Nile virus

Zhao, B. et al., Lobigs, M.

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Disease relevance of WNVgp1

Flavivirus protein biosynthesis involves the proteolytic processing of a single polyprotein precursor by host- and virus-encoded proteinases [1].
The virion structural proteins are encoded in one long open reading frame specifying a polyprotein precursor which is apparently proteolytically cleaved by a mechanism resembling that proposed for expression of structural proteins of other flaviviruses such as yellow fever (YF) and West Nile (WN) viruses [2].

References

Flavivirus premembrane protein cleavage and spike heterodimer secretion require the function of the viral proteinase NS3. Lobigs, M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Cloning full-length dengue type 4 viral DNA sequences: analysis of genes coding for structural proteins. Zhao, B., Mackow, E., Buckler-White, A., Markoff, L., Chanock, R.M., Lai, C.J., Makino, Y. Virology (1986) [Pubmed]

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