Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

coaE - dephospho-CoA kinase

Escherichia coli O157:H7 str. Sakai

O'Toole, N. et al., Nazi, I. et al., Seto, A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of coaE

Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli [1].
ATP-induced structural change of dephosphocoenzyme A kinase from Thermus thermophilus HB8 [2].

High impact information on coaE

The final step in the biosynthesis of CoA is catalyzed by dephosphocoenzyme A kinase (DPCK, E.C. 2.7.1.24) [1].
Dephospho-CoA kinase is structurally similar to many nucleoside kinases and other P-loop-containing nucleotide triphosphate hydrolases, despite having negligible sequence similarity to these enzymes [1].
The method links the enzymes pantothenate kinase, phosphopantotheine adenylyltransferase, and dephosphocoenzyme A kinase in vitro to generate a variety of CoA analogues from chemically synthesized pantothenic acid derivatives [3].
Dephosphocoenzyme A kinase (DCK) catalyzes phosphorylation in the final step of coenzyme A (CoA) biosynthesis [2].

References

Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli. O'Toole, N., Barbosa, J.A., Li, Y., Hung, L.W., Matte, A., Cygler, M. Protein Sci. (2003) [Pubmed]
ATP-induced structural change of dephosphocoenzyme A kinase from Thermus thermophilus HB8. Seto, A., Murayama, K., Toyama, M., Ebihara, A., Nakagawa, N., Kuramitsu, S., Shirouzu, M., Yokoyama, S. Proteins (2005) [Pubmed]
One-pot chemoenzymatic preparation of coenzyme A analogues. Nazi, I., Koteva, K.P., Wright, G.D. Anal. Biochem. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.