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Chemical Compound Review

vitamin B5     3-[[(2R)-2,4-dihydroxy-3,3- dimethyl...

Synonyms: pantothenate, CHEMBL1594, S2498_Selleck, AG-F-30027, CHEBI:46905, ...
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Disease relevance of vitamin B3


Psychiatry related information on vitamin B3


High impact information on vitamin B3


Chemical compound and disease context of vitamin B3


Biological context of vitamin B3

  • In this study we cloned, overexpressed and characterized an enzyme from Bacillus subtilis and its homologue from H. pylori and show that they catalyze the ATP-dependent phosphorylation of pantothenate [14].
  • Imposition of an inside-negative membrane potential caused net uphill pantothenate accumulation in the presence of Na+ but absence of a Na+ gradient, indicating that Na+/pantothenate cotransport is electrogenic [15].
  • Kinetic analysis of the Na+-dependent pantothenate uptake revealed a single transport system which obeyed Michaelis-Menten kinetics (Km = 16 microM and Vmax = 6.7 pmol X mg-1 X 10 s-1) [15].
  • The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites [16].
  • Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit [17].

Anatomical context of vitamin B3


Associations of vitamin B3 with other chemical compounds


Gene context of vitamin B3


Analytical, diagnostic and therapeutic context of vitamin B3


  1. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Sambandamurthy, V.K., Wang, X., Chen, B., Russell, R.G., Derrick, S., Collins, F.M., Morris, S.L., Jacobs, W.R. Nat. Med. (2002) [Pubmed]
  2. Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. Zhang, Y.M., Frank, M.W., Virga, K.G., Lee, R.E., Rock, C.O., Jackowski, S. J. Biol. Chem. (2004) [Pubmed]
  3. Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. Wang, H., Huang, W., Fei, Y.J., Xia, H., Yang-Feng, T.L., Leibach, F.H., Devoe, L.D., Ganapathy, V., Prasad, P.D. J. Biol. Chem. (1999) [Pubmed]
  4. Effects of B vitamin injections on plasma B vitamin concentrations of feed-restricted beef calves infected with bovine herpesvirus-1. Dubeski, P.L., Owens, F.N., Song, W.O., Coburn, S.P., Mahuren, J.D. J. Anim. Sci. (1996) [Pubmed]
  5. HPLC analysis and optimization of enzymatic synthesis of 4'-O-(beta-D-glucopyranosyl)-D-pantothenic acid. Okada, M., Kyoguchi, M., Nakayama, T., Hirota, R., Amachi, T., Ueda, T. J. Nutr. Sci. Vitaminol. (2000) [Pubmed]
  6. Metabolism of pantethine in cystinosis. Wittwer, C.T., Gahl, W.A., Butler, J.D., Zatz, M., Thoene, J.G. J. Clin. Invest. (1985) [Pubmed]
  7. Four intracellular genomes direct weevil biology: nuclear, mitochondrial, principal endosymbiont, and Wolbachia. Heddi, A., Grenier, A.M., Khatchadourian, C., Charles, H., Nardon, P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Pantothenate is required in Neurospora crassa for assembly of subunit peptides of cytochrome c oxidase and ATPase/ATP synthase. Brambl, R., Plesofsky-Vig, N. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  9. Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress. Berruyer, C., Martin, F.M., Castellano, R., Macone, A., Malergue, F., Garrido-Urbani, S., Millet, V., Imbert, J., Duprè, S., Pitari, G., Naquet, P., Galland, F. Mol. Cell. Biol. (2004) [Pubmed]
  10. A mutant of Escherichia coli conditionally defective in the synthesis of holo-[acyl carrier protein]. Polacco, M.L., Cronan, J.E. J. Biol. Chem. (1981) [Pubmed]
  11. Pantothenic acid, coenzyme A, and human chronic ulcerative and granulomatous colitis. Ellestad-Sayed, J.J., Nelson, R.A., Adson, M.A., Palmer, W.M., Soule, E.H. Am. J. Clin. Nutr. (1976) [Pubmed]
  12. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Ottenhof, H.H., Ashurst, J.L., Whitney, H.M., Saldanha, S.A., Schmitzberger, F., Gweon, H.S., Blundell, T.L., Abell, C., Smith, A.G. Plant J. (2004) [Pubmed]
  13. Noxious effects of oxygen reactive species on energy-coupling processes in Ehrlich ascites tumor mitochondria and the protection by pantothenic acid. Slyshenkov, V.S., Moiseenok, A.G., Wojtczak, L. Free Radic. Biol. Med. (1996) [Pubmed]
  14. Characterization of a new pantothenate kinase isoform from Helicobacter pylori. Brand, L.A., Strauss, E. J. Biol. Chem. (2005) [Pubmed]
  15. Pantothenate-sodium cotransport in renal brush-border membranes. Barbarat, B., Podevin, R.A. J. Biol. Chem. (1986) [Pubmed]
  16. The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites. Ivey, R.A., Zhang, Y.M., Virga, K.G., Hevener, K., Lee, R.E., Rock, C.O., Jackowski, S., Park, H.W. J. Biol. Chem. (2004) [Pubmed]
  17. Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. Aprahamian, M., Dentinger, A., Stock-Damgé, C., Kouassi, J.C., Grenier, J.F. Am. J. Clin. Nutr. (1985) [Pubmed]
  18. Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Saliba, K.J., Horner, H.A., Kirk, K. J. Biol. Chem. (1998) [Pubmed]
  19. The mechanism of pantothenate transport by rat liver parenchymal cells in primary culture. Smith, C.M., Milner, R.E. J. Biol. Chem. (1985) [Pubmed]
  20. Human placental brush-border membrane Na(+)-pantothenate cotransport. Grassl, S.M. J. Biol. Chem. (1992) [Pubmed]
  21. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. White, W.H., Gunyuzlu, P.L., Toyn, J.H. J. Biol. Chem. (2001) [Pubmed]
  22. Pantothenate kinase regulation of the intracellular concentration of coenzyme A. Rock, C.O., Calder, R.B., Karim, M.A., Jackowski, S. J. Biol. Chem. (2000) [Pubmed]
  23. The properties and regulation of pantothenate kinase from rat heart. Fisher, M.N., Robishaw, J.D., Neely, J.R. J. Biol. Chem. (1985) [Pubmed]
  24. The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter. Stolz, J., Sauer, N. J. Biol. Chem. (1999) [Pubmed]
  25. The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice). Genschel, U., Powell, C.A., Abell, C., Smith, A.G. Biochem. J. (1999) [Pubmed]
  26. Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae. White, W.H., Skatrud, P.L., Xue, Z., Toyn, J.H. Genetics (2003) [Pubmed]
  27. H+-coupled pantothenate transport in the intracellular malaria parasite. Saliba, K.J., Kirk, K. J. Biol. Chem. (2001) [Pubmed]
  28. The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme a, a coenzyme a antimetabolite. Strauss, E., Begley, T.P. J. Biol. Chem. (2002) [Pubmed]
  29. Pantothenic acid nutritional status in the elderly--institutionalized and noninstitutionalized. Srinivasan, V., Christensen, N., Wyse, B.W., Hansen, R.G. Am. J. Clin. Nutr. (1981) [Pubmed]
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