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Gene Review:

ECs1414 - protein CsgG

Escherichia coli O157:H7 str. Sakai

Robinson, L.S. et al., Hammar, M. et al.

Hammar, Arnqvist, Bian, Olsén, Normark,

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Disease relevance of ECs1414

Antibiotic sensitivity assays demonstrated that overexpression of CsgG rendered Escherichia coli susceptible to the antibiotic erythromycin [1].

High impact information on ECs1414

Directed mutagenesis of CsgG confirmed that its activity is dependent on localization to the outer membrane [1].
No amino acid sequence homologies were found between the CsgE, CsgF and CsgG proteins and secretion/assembly proteins for other known bacterial fibres, suggesting that the formation of curli follows a novel pathway [2].

Analytical, diagnostic and therapeutic context of ECs1414

Rotary Shadow electron microscopy of purified CsgG suggested that this protein assembles into an oligomeric complex with an apparent central pore [1].

References

Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein. Robinson, L.S., Ashman, E.M., Hultgren, S.J., Chapman, M.R. Mol. Microbiol. (2006) [Pubmed]
Expression of two csg operons is required for production of fibronectin- and congo red-binding curli polymers in Escherichia coli K-12. Hammar, M., Arnqvist, A., Bian, Z., Olsén, A., Normark, S. Mol. Microbiol. (1995) [Pubmed]

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