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Chemical Compound Review

Tiloryth     (3R,4S,5R,6R,7R,9R,11R,12R,13S ,14R)-6-[(2R...

Synonyms: Acneryne, AustriaS, Eryacnen, Erycinum, Eryhexal, ...
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Disease relevance of erythromycin


Psychiatry related information on erythromycin


High impact information on erythromycin


Chemical compound and disease context of erythromycin


Biological context of erythromycin


Anatomical context of erythromycin

  • The macrolide antibiotic erythromycin also interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human GI tract [22].
  • The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22 [23].
  • Erythromycin, a potent inhibitor of bacterial protein synthesis, at a concentration that completely inhibits L. pneumophila intracellular multiplication, had no influence on fusion of L. pneumophila phagosomes with secondary lysosomes [24].
  • Erythromycin, at concentrations that completely inhibit the intracellular multiplication of L. pneumophila, has no effect on vacuole formation [25].
  • The rate of demethylation of this substrate, measured simply as 14CO2 in the breath, correlated well with the concentrations of immunoreactive P-450p protein (r = 0.70), holocytochrome P-450p (r = 0.70), or with erythromycin N-demethylase activity (r = 0.90) determined in the liver microsomes prepared from each rat [26].

Associations of erythromycin with other chemical compounds


Gene context of erythromycin


Analytical, diagnostic and therapeutic context of erythromycin


  1. Improvement of gastric emptying in diabetic gastroparesis by erythromycin. Preliminary studies. Janssens, J., Peeters, T.L., Vantrappen, G., Tack, J., Urbain, J.L., De Roo, M., Muls, E., Bouillon, R. N. Engl. J. Med. (1990) [Pubmed]
  2. Experience with the routine use of erythromycin for chlamydial infections in pregnancy. Schachter, J., Sweet, R.L., Grossman, M., Landers, D., Robbie, M., Bishop, E. N. Engl. J. Med. (1986) [Pubmed]
  3. Resistance to erythromycin in group A streptococci. Seppälä, H., Nissinen, A., Järvinen, H., Huovinen, S., Henriksson, T., Herva, E., Holm, S.E., Jahkola, M., Katila, M.L., Klaukka, T. N. Engl. J. Med. (1992) [Pubmed]
  4. Ototoxicity of erythromycin in patients with renal insufficiency. Méry, J.P., Kanfer, A. N. Engl. J. Med. (1979) [Pubmed]
  5. Gastrointestinal motor effects of erythromycin in humans. Sarna, S.K., Soergel, K.H., Koch, T.R., Stone, J.E., Wood, C.M., Ryan, R.P., Arndorfer, R.C., Cavanaugh, J.H., Nellans, H.N., Lee, M.B. Gastroenterology (1991) [Pubmed]
  6. Erythromycin effects on gastric emptying, antral motility and plasma motilin and pancreatic polypeptide concentrations in anorexia nervosa. Stacher, G., Peeters, T.L., Bergmann, H., Wiesnagrotzki, S., Schneider, C., Granser-Vacariu, G.V., Gaupmann, G., Kugi, A. Gut (1993) [Pubmed]
  7. Erythromycin inhibits tumor necrosis factor alpha and interleukin 6 production induced by heat-killed Streptococcus pneumoniae in whole blood. Schultz, M.J., Speelman, P., Zaat, S., van Deventer, S.J., van der Poll, T. Antimicrob. Agents Chemother. (1998) [Pubmed]
  8. Azithromycin and clarithromycin: overview and comparison with erythromycin. Whitman, M.S., Tunkel, A.R. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (1992) [Pubmed]
  9. Effects of food deprivation and adrenalectomy on CYP3A induction by RU486 in female rats. Cheesman, M.J., Mason, S.R., Reilly, P.E. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  10. The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. Finnish Study Group for Antimicrobial Resistance. Seppälä, H., Klaukka, T., Vuopio-Varkila, J., Muotiala, A., Helenius, H., Lager, K., Huovinen, P. N. Engl. J. Med. (1997) [Pubmed]
  11. Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. Hauth, J.C., Goldenberg, R.L., Andrews, W.W., DuBard, M.B., Copper, R.L. N. Engl. J. Med. (1995) [Pubmed]
  12. A controlled trial of povidone-iodine as prophylaxis against ophthalmia neonatorum. Isenberg, S.J., Apt, L., Wood, M. N. Engl. J. Med. (1995) [Pubmed]
  13. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Schlünzen, F., Zarivach, R., Harms, J., Bashan, A., Tocilj, A., Albrecht, R., Yonath, A., Franceschi, F. Nature (2001) [Pubmed]
  14. Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Cortes, J., Wiesmann, K.E., Roberts, G.A., Brown, M.J., Staunton, J., Leadlay, P.F. Science (1995) [Pubmed]
  15. The increasing incidence of Ampicillin-resistant Haemophilus influenzae. A cause of otitis media. Schwartz, R., Rodriguez, W., Khan, W., Ross, S. JAMA (1978) [Pubmed]
  16. Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. Looareesuwan, S., Phillips, R.E., White, N.J., Karbwang, J., Benjasurat, Y., Attanath, P., Warrell, D.A. Lancet (1985) [Pubmed]
  17. Treatment of the early manifestations of Lyme disease. Steere, A.C., Hutchinson, G.J., Rahn, D.W., Sigal, L.H., Craft, J.E., DeSanna, E.T., Malawista, S.E. Ann. Intern. Med. (1983) [Pubmed]
  18. Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. Pieper, R., Luo, G., Cane, D.E., Khosla, C. Nature (1995) [Pubmed]
  19. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Cortes, J., Haydock, S.F., Roberts, G.A., Bevitt, D.J., Leadlay, P.F. Nature (1990) [Pubmed]
  20. Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Marsden, A.F., Caffrey, P., Aparicio, J.F., Loughran, M.S., Staunton, J., Leadlay, P.F. Science (1994) [Pubmed]
  21. Macrolide resistance among invasive Streptococcus pneumoniae isolates. Hyde, T.B., Gay, K., Stephens, D.S., Vugia, D.J., Pass, M., Johnson, S., Barrett, N.L., Schaffner, W., Cieslak, P.R., Maupin, P.S., Zell, E.R., Jorgensen, J.H., Facklam, R.R., Whitney, C.G. JAMA (2001) [Pubmed]
  22. Receptor for motilin identified in the human gastrointestinal system. Feighner, S.D., Tan, C.P., McKee, K.K., Palyha, O.C., Hreniuk, D.L., Pong, S.S., Austin, C.P., Figueroa, D., MacNeil, D., Cascieri, M.A., Nargund, R., Bakshi, R., Abramovitz, M., Stocco, R., Kargman, S., O'Neill, G., Van Der Ploeg, L.H., Evans, J., Patchett, A.A., Smith, R.G., Howard, A.D. Science (1999) [Pubmed]
  23. The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22. Gabashvili, I.S., Gregory, S.T., Valle, M., Grassucci, R., Worbs, M., Wahl, M.C., Dahlberg, A.E., Frank, J. Mol. Cell (2001) [Pubmed]
  24. The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. Horwitz, M.A. J. Exp. Med. (1983) [Pubmed]
  25. Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. Horwitz, M.A. J. Exp. Med. (1983) [Pubmed]
  26. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. Watkins, P.B., Murray, S.A., Winkelman, L.G., Heuman, D.M., Wrighton, S.A., Guzelian, P.S. J. Clin. Invest. (1989) [Pubmed]
  27. Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. Lindenbaum, J., Rund, D.G., Butler, V.P., Tse-Eng, D., Saha, J.R. N. Engl. J. Med. (1981) [Pubmed]
  28. Clostridial myonecrosis ('gas gangrene') during cephalosporin prophylaxis. Mohr, J.A., Griffiths, W., Holm, R., Garcia-Moral, C., Flournoy, D.J. JAMA (1978) [Pubmed]
  29. Antibiotic depression of evoked and spontaneous responses of opossum distal colonic muscularis mucosae in vitro: a factor in antibiotic-associated colitis? Percy, W.H., Christensen, J. Gastroenterology (1985) [Pubmed]
  30. Randomised comparison of amoxycillin and erythromycin in treatment of genital chlamydial infection in pregnancy. Alary, M., Joly, J.R., Moutquin, J.M., Mondor, M., Boucher, M., Fortier, A., Pinault, J.J., Paris, G., Carrier, S., Chamberland, H. Lancet (1994) [Pubmed]
  31. Doxycycline modulates nitric oxide production in murine lung epithelial cells. Hoyt, J.C., Ballering, J., Numanami, H., Hayden, J.M., Robbins, R.A. J. Immunol. (2006) [Pubmed]
  32. Effect of CYP3A inhibition on vesnarinone metabolism in humans. Wandel, C., Lang, C.C., Cowart, D.C., Girard, A.F., Bramer, S., Flockhart, D.A., Wood, A.J. Clin. Pharmacol. Ther. (1998) [Pubmed]
  33. Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease. Dowling, T.C., Briglia, A.E., Fink, J.C., Hanes, D.S., Light, P.D., Stackiewicz, L., Karyekar, C.S., Eddington, N.D., Weir, M.R., Henrich, W.L. Clin. Pharmacol. Ther. (2003) [Pubmed]
  34. Mdr1 limits CYP3A metabolism in vivo. Lan, L.B., Dalton, J.T., Schuetz, E.G. Mol. Pharmacol. (2000) [Pubmed]
  35. The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast. Lafontaine, D., Delcour, J., Glasser, A.L., Desgrès, J., Vandenhaute, J. J. Mol. Biol. (1994) [Pubmed]
  36. Acute eosinophilic pneumonia as a reversible cause of noninfectious respiratory failure. Allen, J.N., Pacht, E.R., Gadek, J.E., Davis, W.B. N. Engl. J. Med. (1989) [Pubmed]
  37. Cardiac actions of erythromycin: influence of female sex. Drici, M.D., Knollmann, B.C., Wang, W.X., Woosley, R.L. JAMA (1998) [Pubmed]
  38. Improved pregnancy outcome following successful treatment of chlamydial infection. Cohen, I., Veille, J.C., Calkins, B.M. JAMA (1990) [Pubmed]
  39. Recurrent epidemics caused by a single strain of erythromycin-resistant Staphylococcus aureus. The importance of molecular epidemiology. Back, N.A., Linnemann, C.C., Pfaller, M.A., Staneck, J.L., Morthland, V. JAMA (1993) [Pubmed]
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