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Chemical Compound Review

Tiloryth     (3R,4S,5R,6R,7R,9R,11R,12R,13S ,14R)-6-[(2R...

Synonyms: Acneryne, AustriaS, Eryacnen, Erycinum, Eryhexal, ...
 
 
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Disease relevance of erythromycin

 

Psychiatry related information on erythromycin

 

High impact information on erythromycin

 

Chemical compound and disease context of erythromycin

 

Biological context of erythromycin

 

Anatomical context of erythromycin

  • The macrolide antibiotic erythromycin also interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human GI tract [22].
  • The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22 [23].
  • Erythromycin, a potent inhibitor of bacterial protein synthesis, at a concentration that completely inhibits L. pneumophila intracellular multiplication, had no influence on fusion of L. pneumophila phagosomes with secondary lysosomes [24].
  • Erythromycin, at concentrations that completely inhibit the intracellular multiplication of L. pneumophila, has no effect on vacuole formation [25].
  • The rate of demethylation of this substrate, measured simply as 14CO2 in the breath, correlated well with the concentrations of immunoreactive P-450p protein (r = 0.70), holocytochrome P-450p (r = 0.70), or with erythromycin N-demethylase activity (r = 0.90) determined in the liver microsomes prepared from each rat [26].
 

Associations of erythromycin with other chemical compounds

 

Gene context of erythromycin

 

Analytical, diagnostic and therapeutic context of erythromycin

References

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  3. Resistance to erythromycin in group A streptococci. Seppälä, H., Nissinen, A., Järvinen, H., Huovinen, S., Henriksson, T., Herva, E., Holm, S.E., Jahkola, M., Katila, M.L., Klaukka, T. N. Engl. J. Med. (1992) [Pubmed]
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  6. Erythromycin effects on gastric emptying, antral motility and plasma motilin and pancreatic polypeptide concentrations in anorexia nervosa. Stacher, G., Peeters, T.L., Bergmann, H., Wiesnagrotzki, S., Schneider, C., Granser-Vacariu, G.V., Gaupmann, G., Kugi, A. Gut (1993) [Pubmed]
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  14. Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Cortes, J., Wiesmann, K.E., Roberts, G.A., Brown, M.J., Staunton, J., Leadlay, P.F. Science (1995) [Pubmed]
  15. The increasing incidence of Ampicillin-resistant Haemophilus influenzae. A cause of otitis media. Schwartz, R., Rodriguez, W., Khan, W., Ross, S. JAMA (1978) [Pubmed]
  16. Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. Looareesuwan, S., Phillips, R.E., White, N.J., Karbwang, J., Benjasurat, Y., Attanath, P., Warrell, D.A. Lancet (1985) [Pubmed]
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  20. Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Marsden, A.F., Caffrey, P., Aparicio, J.F., Loughran, M.S., Staunton, J., Leadlay, P.F. Science (1994) [Pubmed]
  21. Macrolide resistance among invasive Streptococcus pneumoniae isolates. Hyde, T.B., Gay, K., Stephens, D.S., Vugia, D.J., Pass, M., Johnson, S., Barrett, N.L., Schaffner, W., Cieslak, P.R., Maupin, P.S., Zell, E.R., Jorgensen, J.H., Facklam, R.R., Whitney, C.G. JAMA (2001) [Pubmed]
  22. Receptor for motilin identified in the human gastrointestinal system. Feighner, S.D., Tan, C.P., McKee, K.K., Palyha, O.C., Hreniuk, D.L., Pong, S.S., Austin, C.P., Figueroa, D., MacNeil, D., Cascieri, M.A., Nargund, R., Bakshi, R., Abramovitz, M., Stocco, R., Kargman, S., O'Neill, G., Van Der Ploeg, L.H., Evans, J., Patchett, A.A., Smith, R.G., Howard, A.D. Science (1999) [Pubmed]
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  25. Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. Horwitz, M.A. J. Exp. Med. (1983) [Pubmed]
  26. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. Watkins, P.B., Murray, S.A., Winkelman, L.G., Heuman, D.M., Wrighton, S.A., Guzelian, P.S. J. Clin. Invest. (1989) [Pubmed]
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  30. Randomised comparison of amoxycillin and erythromycin in treatment of genital chlamydial infection in pregnancy. Alary, M., Joly, J.R., Moutquin, J.M., Mondor, M., Boucher, M., Fortier, A., Pinault, J.J., Paris, G., Carrier, S., Chamberland, H. Lancet (1994) [Pubmed]
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  33. Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease. Dowling, T.C., Briglia, A.E., Fink, J.C., Hanes, D.S., Light, P.D., Stackiewicz, L., Karyekar, C.S., Eddington, N.D., Weir, M.R., Henrich, W.L. Clin. Pharmacol. Ther. (2003) [Pubmed]
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  37. Cardiac actions of erythromycin: influence of female sex. Drici, M.D., Knollmann, B.C., Wang, W.X., Woosley, R.L. JAMA (1998) [Pubmed]
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  39. Recurrent epidemics caused by a single strain of erythromycin-resistant Staphylococcus aureus. The importance of molecular epidemiology. Back, N.A., Linnemann, C.C., Pfaller, M.A., Staneck, J.L., Morthland, V. JAMA (1993) [Pubmed]
 
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