Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ECs3254 - formyl-coenzyme A transferase

Escherichia coli O157:H7 str. Sakai

Rangarajan, E.S. et al., Gruez, A. et al., Ricagno, S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ECs3254

The frc ortholog in E. coli is yfdW, with which it shares 61% sequence identity [1].
The monomer and dimer resemble those of formyl-CoA transferase from Oxalobacter formigenes, as well as E. coli YfdW, a putative type-III CoA transferase of unknown function [2].

High impact information on ECs3254

Oxalate degradation was found to be performed successively by two enzymes, a formyl-CoA transferase (frc) and an oxalate decarboxylase (oxc) [1].
While the location of cofactor binding is similar in the three proteins, the specific CoA-protein interactions vary somewhat between CaiB, formyl-CoA transferase, and YfdW [2].
Crystals of formyl-CoA transferase were grown at 293 K using polyethylene glycol 4000 as a precipitant [3].
Formyl-CoA transferase was crystallized both as the apoenzyme and as its complex with coenzyme A [3].

References

The crystal structure of the Escherichia coli YfdW gene product reveals a new fold of two interlaced rings identifying a wide family of CoA transferases. Gruez, A., Roig-Zamboni, V., Valencia, C., Campanacci, V., Cambillau, C. J. Biol. Chem. (2003) [Pubmed]
Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA. Rangarajan, E.S., Li, Y., Iannuzzi, P., Cygler, M., Matte, A. Biochemistry (2005) [Pubmed]
Crystallization and preliminary crystallographic analysis of formyl-CoA tranferase from Oxalobacter formigenes. Ricagno, S., Jonsson, S., Richards, N., Lindqvist, Y. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.