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Chemical Compound Review

AC1LCVPZ     2-[2-[2-[2-[2-[2-[2-[2-[2-[2- [2-[2-[2-(2...

Synonyms: AG-G-54881, CTK2F4647, 67411-64-7, PE3, EINECS 266-688-1
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Disease relevance of polyethylene glycol


Psychiatry related information on polyethylene glycol


High impact information on polyethylene glycol


Chemical compound and disease context of polyethylene glycol


Biological context of polyethylene glycol


Anatomical context of polyethylene glycol


Associations of polyethylene glycol with other chemical compounds


Gene context of polyethylene glycol

  • In contrast, injection of a polyethylene glycol-modified form of granulocyte/macrophage colony-stimulating factor (GM-CSF) into mice only expands the myeloid-related DC subset [32].
  • The present studies describe a molecular reformulation of BDNF that incorporates polyethylene glycol (PEG) moieties at surface carboxyl residues, to optimize plasma pharmacokinetics, and links pegylated BDNF to the OX26 mAb, which undergoes receptor-mediated transport through the BBB via the brain capillary endothelial transferrin receptor [33].
  • NER supported by nuclear extracts requires ATP and Mg2+ and is stimulated by polyethylene glycol and by small amounts of whole cell extract containing overexpressed Rad2 protein [34].
  • Enforced expression of c-mpl in embryonic stem (ES) cells inactivated for this gene results in protein expression in all the ES cell progeny, producing cells that do not belong to the megakaryocytic lineage and are responsive to PEG-rhuMGDF, a truncated form of human thrombopoietin (TPO) conjugated to polyethylene glycol [35].
  • Binding of IL 1 to the solubilized receptor was detected by a polyethylene glycol (PEG) precipitation procedure [36].

Analytical, diagnostic and therapeutic context of polyethylene glycol


  1. Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. Heathcote, E.J., Shiffman, M.L., Cooksley, W.G., Dusheiko, G.M., Lee, S.S., Balart, L., Reindollar, R., Reddy, R.K., Wright, T.L., Lin, A., Hoffman, J., De Pamphilis, J. N. Engl. J. Med. (2000) [Pubmed]
  2. Reversal of X-inactivation in female mouse somatic cells hybridized with murine teratocarcinoma stem cells in vitro. Takagi, N., Yoshida, M.A., Sugawara, O., Sasaki, M. Cell (1983) [Pubmed]
  3. Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase. Hershfield, M.S., Buckley, R.H., Greenberg, M.L., Melton, A.L., Schiff, R., Hatem, C., Kurtzberg, J., Markert, M.L., Kobayashi, R.H., Kobayashi, A.L. N. Engl. J. Med. (1987) [Pubmed]
  4. Lateral mobility of human erythrocyte integral membrane proteins. Fowler, V., Branton, D. Nature (1977) [Pubmed]
  5. Motor activity recorded in the unprepared colon of healthy humans. Lémann, M., Flourié, B., Picon, L., Coffin, B., Jian, R., Rambaud, J.C. Gut (1995) [Pubmed]
  6. Immunochemical determination of serum albumin with a centrifugal analyzer. Blom, M., Hjørne, N. Clin. Chem. (1975) [Pubmed]
  7. Efficacy and optimal dose of daily polyethylene glycol 3350 for treatment of constipation and encopresis in children. Canning, D.A. J. Urol. (2003) [Pubmed]
  8. Construction and characterization of a proU-gfp transcriptional fusion that measures water availability in a microbial habitat. Axtell, C.A., Beattie, G.A. Appl. Environ. Microbiol. (2002) [Pubmed]
  9. Changes in self-stimulation at stimulation-bound eating and drinking sites in the lateral hypothalamus during food or water deprivation, glucoprivation, and intracellular or extracellular dehydration. Frutiger, S.A. Behav. Neurosci. (1986) [Pubmed]
  10. Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Strathdee, C.A., Duncan, A.M., Buchwald, M. Nat. Genet. (1992) [Pubmed]
  11. Cytoplasmic activation of human nuclear genes in stable heterocaryons. Blau, H.M., Chiu, C.P., Webster, C. Cell (1983) [Pubmed]
  12. Phenotypic complementation of the SV40 tsA mutant defect in viral DNA synthesis following microinjection of SV40 T antigen. Kriegler, M.P., Griffin, J.D., Livingston, D.M. Cell (1978) [Pubmed]
  13. Monoclonal antibody production by receptor-mediated electrically induced cell fusion. Lo, M.M., Tsong, T.Y., Conrad, M.K., Strittmatter, S.M., Hester, L.D., Snyder, S.H. Nature (1984) [Pubmed]
  14. Intestinal permeability in patients with Crohn's disease and their healthy relatives. Katz, K.D., Hollander, D., Vadheim, C.M., McElree, C., Delahunty, T., Dadufalza, V.D., Krugliak, P., Rotter, J.I. Gastroenterology (1989) [Pubmed]
  15. Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution. Brady, C.E., DiPalma, J.A., Morawski, S.G., Santa Ana, C.A., Fordtran, J.S. Gastroenterology (1986) [Pubmed]
  16. Influence of meal composition on canine jejunal water and electrolyte absorption. Bastidas, J.A., Zinner, M.J., Bastidas, J.A., Orandle, M.S., Yeo, C.J. Gastroenterology (1992) [Pubmed]
  17. Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. Steinbrecher, K.A., Mann, E.A., Giannella, R.A., Cohen, M.B. Gastroenterology (2001) [Pubmed]
  18. One-step preparation of competent Escherichia coli: transformation and storage of bacterial cells in the same solution. Chung, C.T., Niemela, S.L., Miller, R.H. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  19. IgG antibody response to polyethylene glycol-modified adenosine deaminase in patients with adenosine deaminase deficiency. Chaffee, S., Mary, A., Stiehm, E.R., Girault, D., Fischer, A., Hershfield, M.S. J. Clin. Invest. (1992) [Pubmed]
  20. Role of volume in the regulation of vasopressin secretion during pregnancy in the rat. Barron, W.M., Stamoutsos, B.A., Lindheimer, M.D. J. Clin. Invest. (1984) [Pubmed]
  21. Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine. Iinuma, T., Homma, S., Noda, T., Kufe, D., Ohno, T., Toda, G. J. Clin. Invest. (2004) [Pubmed]
  22. Polyethylene glycol 400 penetration of the colonic epithelial barrier of the rat. Krugliak, P., Hollander, D., Schlaepfer, C.C., Katz, K.D., Dadufalza, V.D., Ma, T.Y. Gastroenterology (1990) [Pubmed]
  23. Intestinal permeability in patients with eczema and food allergy. Jackson, P.G., Lessof, M.H., Baker, R.W., Ferrett, J., MacDonald, D.M. Lancet (1981) [Pubmed]
  24. Fusion of hen erythrocytes with yeast protoplasts induced by polyethylene glycol. Ahkong, Q.F., Howell, J.I., Lucy, J.A., Safwat, F., Davey, M.R., Cocking, E.C. Nature (1975) [Pubmed]
  25. Time and mode of fusion of human fibroblasts treated with polyethylene glycol (PEG). Pontecorvo, G., Riddle, P.N., Hales, A. Nature (1977) [Pubmed]
  26. Interkingdom fusion between human (HeLa) cells and tobacco hybrid (GGLL) protoplasts. Jones, C.W., Mastrangelo, I.A., Smith, H.H., Liu, H.Z., Meck, R.A. Science (1976) [Pubmed]
  27. Growth of SJL/J-derived transplantable reticulum cell sarcoma as related to its ability to induce T-cell proliferation in the host. I. Dominant negative genetic influences of other parent haplotype in F1 hybrids of SJL/J mice. Katz, I.R., Lerman, S.P., Ponzio, N.M., Shreffler, D.C., Thorbecke, G.J. J. Exp. Med. (1980) [Pubmed]
  28. Production of autoantibodies by human-human hybridomas. Shoenfeld, Y., Hsu-Lin, S.C., Gabriels, J.E., Silberstein, L.E., Furie, B.C., Furie, B., Stollar, B.D., Schwartz, R.S. J. Clin. Invest. (1982) [Pubmed]
  29. Human coagluation factor V purification and thrombin-catalyzed activation. Dahlbäck, B. J. Clin. Invest. (1980) [Pubmed]
  30. Circulating DNA:anti-DNA complexes in systemic lupus erythematosus. Detection and characterization by ultracentrifugation. Bruneau, C., Benveniste, J. J. Clin. Invest. (1979) [Pubmed]
  31. Effect of ileal perfusion of carbohydrates and amylase inhibitor on gastrointestinal hormones and emptying. Jain, N.K., Boivin, M., Zinsmeister, A.R., Brown, M.L., Malagelada, J.R., DiMagno, E.P. Gastroenterology (1989) [Pubmed]
  32. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Pulendran, B., Smith, J.L., Caspary, G., Brasel, K., Pettit, D., Maraskovsky, E., Maliszewski, C.R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  33. Neuroprotection with noninvasive neurotrophin delivery to the brain. Wu, D., Pardridge, W.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  34. Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae. Wang, Z., Wu, X., Friedberg, E.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  35. Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro. Filippi, M.D., Porteu, F., Pesteur, F.L., Schiavon, V., Millot, G.A., Vainchenker, W., de Sauvage, F.J., Dubart Kupperschmitt, A., Sainteny, F. Blood (2002) [Pubmed]
  36. Detergent solubilization of the interleukin 1 receptor. Paganelli, K.A., Stern, A.S., Kilian, P.L. J. Immunol. (1987) [Pubmed]
  37. Pancreatic enzyme response to a liquid meal and to hormonal stimulation. Correlation with plasma secretin and cholecystokinin levels. Beglinger, C., Fried, M., Whitehouse, I., Jansen, J.B., Lamers, C.B., Gyr, K. J. Clin. Invest. (1985) [Pubmed]
  38. Sperm-related antigens, antibodies, and circulating immune complexes in sera of recently vasectomized men. Witkin, S.S., Zelikovsky, G., Bongiovanni, A.M., Geller, N., Good, R.A., Day, N.K. J. Clin. Invest. (1982) [Pubmed]
  39. A solid-phase radioimmunoassay for Epstein-Barr virus-associated membrane antigen prepared from B95-8 cell culture supernatants. Dölken, G., Klein, G. J. Natl. Cancer Inst. (1977) [Pubmed]
  40. T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase. Weinberg, K., Hershfield, M.S., Bastian, J., Kohn, D., Sender, L., Parkman, R., Lenarsky, C. J. Clin. Invest. (1993) [Pubmed]
  41. Protein precipitation by acetone for the analysis of polyethylene glycol in intestinal perfusion fluid. Buxton, T.B., Crockett, J.K., Moore, W.L., Moore, W.L., Rissing, J.P. Gastroenterology (1979) [Pubmed]
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