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Gene Review:

ECs0922 - proton motive force efflux pump

Escherichia coli O157:H7 str. Sakai

Kobayashi, A. et al., Wei, Y. et al., Bohn, C. et al.

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Disease relevance of ECs0922

MMC resistance is caused by the presence of any of four distinct E. coli genes (mdfA, gyrl, rob, and sdiA) on high-copy-number vectors. mdfA encodes a membrane efflux pump whose overexpression results in broad-spectrum chemical resistance [1].

High impact information on ECs0922

The expression of acrAB, emrAB, emrD, emrE, emrKY, mdfA, and ydgFE is stable at moderate levels during any growth phase, whereas mdtEF promoter activity greatly increased with cell growth and reached the maximum level at the late stationary phase [2].
The previously reported cmlA1 mutation confers a similar phenotype. cmlA1 contains an IS30 insertion upstream of cmr/mdfA, which creates a putative promoter [3].

References

In vivo titration of mitomycin C action by four Escherichia coli genomic regions on multicopy plasmids. Wei, Y., Vollmer, A.C., LaRossa, R.A. J. Bacteriol. (2001) [Pubmed]
Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance. Kobayashi, A., Hirakawa, H., Hirata, T., Nishino, K., Yamaguchi, A. J. Bacteriol. (2006) [Pubmed]
The Escherichia coli cmlA gene encodes the multidrug efflux pump Cmr/MdfA and is responsible for isopropyl-beta-D-thiogalactopyranoside exclusion and spectinomycin sensitivity. Bohn, C., Bouloc, P. J. Bacteriol. (1998) [Pubmed]

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