Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

mdfA - multidrug efflux system protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0832, JW0826, cmlA, cmr

Nilsen, I.W. et al.

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Disease relevance of cmr

Isolation of cmr, a novel Escherichia coli chloramphenicol resistance gene encoding a putative efflux pump [1].

High impact information on cmr

A novel gene designated cmr, which mapped to 18.8 min of the Escherichia coli K-12 genome, was shown to mediate resistance to chloramphenicol when it was expressed from a multicopy vector [1].

Associations of cmr with chemical compounds

The accumulation of chloramphenicol was significantly less in cells overexpressing cmr than in control cells harboring the vector without insert [1].

References

Isolation of cmr, a novel Escherichia coli chloramphenicol resistance gene encoding a putative efflux pump. Nilsen, I.W., Bakke, I., Vader, A., Olsvik, O., El-Gewely, M.R. J. Bacteriol. (1996) [Pubmed]

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