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Gene Review:

lpxK - tetraacyldisaccharide 4'-kinase

Escherichia coli O157:H7 str. Sakai

Wang, X. et al., Garrett, T.A. et al., Ray, B.L. et al.

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Disease relevance of ECs0998

Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK [1].
Although a functional orthologue of lpxK, the gene encoding the lipid A 4'-kinase, is present in Francisella, no 4'-phosphate moiety is attached to Francisella lipid A [2].

High impact information on ECs0998

The lipid A 4'-kinase is distinct from the diglyceride kinase of E. coli [3].

References

Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. Garrett, T.A., Kadrmas, J.L., Raetz, C.R. J. Biol. Chem. (1997) [Pubmed]
Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF. Wang, X., McGrath, S.C., Cotter, R.J., Raetz, C.R. J. Biol. Chem. (2006) [Pubmed]
The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A. Ray, B.L., Raetz, C.R. J. Biol. Chem. (1987) [Pubmed]

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