Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

L - polymerase

Spring viraemia of carp virus

Björklund, H.V. et al., Roy, P. et al., Mork, C. et al.

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Disease relevance of L

S-adenosyl-L-methionine was not particularly effective in stimulating the virion RNA polymerase activity of vesicular stomatitis virus or pike fry rhabdovirus [1].
An RNA-dependent RNA polymerase activity has been demonstrated for spring viremia of carp virus (SVCV) [1].
At this point we have deduced the amino acid sequences and analysed the first 1,400 amino acids comprising two thirds of the polymerase genes of SVCV and IHNV [2].
The SVCV polymerase showed the closest relationship with the vesicular stomatitis virus polymerases and also shared significant sequence identity with the polymerase of rabies virus [2].

High impact information on L

We have determined the partial nucleotide sequences of the polymerase genes of the fish rhabdoviruses, spring viremia of carp virus (SVCV) and infectious hematopoietic necrosis virus (IHNV) [2].

Analytical, diagnostic and therapeutic context of L

In addition, sequence analysis of 2678 nt of the amino portion of the viral polymerase gene indicated that SFRV was genetically distinct from other members of the family Rhabdoviridae for which sequence data are available [3].

References

Spring viremia of carp virus RNA and virion-associated transcriptase activity. Roy, P., Clewley, J.P. J. Virol. (1978) [Pubmed]
Comparison of the polymerases (L genes) of spring viremia of carp virus and infectious hematopoietic necrosis virus. Björklund, H.V., Emmenegger, E.J., Kurath, G. Vet. Res. (1995) [Pubmed]
Isolation and characterization of a rhabdovirus from starry flounder (Platichthys stellatus) collected from the northern portion of Puget Sound, Washington, USA. Mork, C., Hershberger, P., Kocan, R., Batts, W., Winton, J. J. Gen. Virol. (2004) [Pubmed]

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