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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Infectious hematopoietic necrosis virus

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Disease relevance of Infectious hematopoietic necrosis virus


High impact information on Infectious hematopoietic necrosis virus

  • Finally, we demonstrated that the SHRV glycoprotein can be replaced by the glycoprotein of infectious hematopoietic necrosis virus (IHNV) or by a hybrid protein composed of SHRV and IHNV sequences [6].
  • Although IHNV and VHSV NV proteins do not share any significant identity, we show here that both NV proteins play a similar role since a recombinant IHNV virus, rIHNV-NV(VHSV), in which the IHNV NV open reading frame has been replaced by that of VHSV, was shown to replicate as well as the wild-type (wt) IHNV into fish cells [7].
  • Furthermore, we show that juvenile trout immunized with NV-knockout IHNV were protected against challenge with wt IHNV [7].
  • By using a recently developed reverse-genetic system based on IHNV (S. Biacchesi et al., J. Virol. 74:11247-11253, 2000), we investigated the ability to exchange IHNV glycoprotein G with that of VHSV [8].
  • Incubation of IHNV with soluble FN2 before addition to cells also increased infection [9].

Chemical compound and disease context of Infectious hematopoietic necrosis virus


Biological context of Infectious hematopoietic necrosis virus


Anatomical context of Infectious hematopoietic necrosis virus

  • The use of infectious hematopietic necrosis virus (IHNV) recombinant viruses, expressing the VHSV G protein, further substantiated the VHSV G-protein specificity of the 8 aa Vbeta4-Jbeta1 response and designated the 6 aa Vbeta4-Jbeta1 response as potentially directed to a T-cell epitope common to VHSV and IHNV [17].
  • By contrast, these cell lines were generally resistant to VHSV, IHNV and IPNV, with varying susceptibility to RC and CCV [18].

Gene context of Infectious hematopoietic necrosis virus

  • Molecular epizootiology and evolution of the glycoprotein and non-virion protein genes of infectious hematopoietic necrosis virus, a fish rhabdovirus [19].
  • Our results showed that neither the internal structural proteins (N, P and M) nor the NV protein of IHNV induced protective immunity in fry or neutralizing antibodies in fry and 150 g fish when expressed by a DNA vaccine construct [20].
  • We present here the sequence of the VHSV NV gene and demonstrate the presence of IHNV and VHSV NV proteins in virus-infected cells [21].
  • Sequence comparisons between the M2 protein genes of HRV and those of IHNV and VHSV revealed similarities of 71.3 and 45.4% at the nucleotide level and 86.0 and 57.0% at the amino acid level, respectively [22].
  • We have constructed a plasmid which carries a full length cDNA copy of the IHNV NV gene between 2 RNA polymerase promoters such that plus-sense and minus-sense RNA transcripts of the IHNV NV gene can be synthesized [23].

Analytical, diagnostic and therapeutic context of Infectious hematopoietic necrosis virus


  1. Nucleotide sequence of a cDNA clone carrying the glycoprotein gene of infectious hematopoietic necrosis virus, a fish rhabdovirus. Koener, J.F., Passavant, C.W., Kurath, G., Leong, J. J. Virol. (1987) [Pubmed]
  2. Bacterially expressed nucleoprotein of infectious hematopoietic necrosis virus augments protective immunity induced by the glycoprotein vaccine in fish. Oberg, L.A., Wirkkula, J., Mourich, D., Leong, J.C. J. Virol. (1991) [Pubmed]
  3. Neutralization-resistant variants of infectious hematopoietic necrosis virus have altered virulence and tissue tropism. Kim, C.H., Winton, J.R., Leong, J.C. J. Virol. (1994) [Pubmed]
  4. The structural proteins of infectious pancreatic virus are not glycosylated. Perez, L., Chiou, P.P., Leong, J.C. J. Virol. (1996) [Pubmed]
  5. Recombinant infectious hematopoietic necrosis virus and viral hemorrhagic septicemia virus glycoprotein epitopes expressed in Aeromonas salmonicida induce protective immunity in rainbow trout (Oncorhynchus mykiss). Noonan, B., Enzmann, P.J., Trust, T.J. Appl. Environ. Microbiol. (1995) [Pubmed]
  6. The NV gene of snakehead rhabdovirus (SHRV) is not required for pathogenesis, and a heterologous glycoprotein can be incorporated into the SHRV envelope. Alonso, M., Kim, C.H., Johnson, M.C., Pressley, M., Leong, J.A. J. Virol. (2004) [Pubmed]
  7. Essential role of the NV protein of Novirhabdovirus for pathogenicity in rainbow trout. Thoulouze, M.I., Bouguyon, E., Carpentier, C., Brémont, M. J. Virol. (2004) [Pubmed]
  8. Heterologous exchanges of the glycoprotein and the matrix protein in a Novirhabdovirus. Biacchesi, S., Béarzotti, M., Bouguyon, E., Brémont, M. J. Virol. (2002) [Pubmed]
  9. Novel form of fibronectin from zebrafish mediates infectious hematopoietic necrosis virus infection. Liu, X., Collodi, P. J. Virol. (2002) [Pubmed]
  10. A novel 90-kDa stress protein induced in fish cells by fish rhabdovirus infection. Cho, W.J., Cha, S.J., Do, J.W., Choi, J.Y., Lee, J.Y., Jeong, C.S., Cho, K.J., Choi, W.S., Kang, H.S., Kim, H.D., Park, J.W. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  11. Naked DNA vaccination of Atlantic salmon Salmo salar against IHNV. Traxler, G.S., Anderson, E., LaPatra, S.E., Richard, J., Shewmaker, B., Kurath, G. Dis. Aquat. Org. (1999) [Pubmed]
  12. Synergistic effects of esfenvalerate and infectious hematopoietic necrosis virus on juvenile chinook salmon mortality. Clifford, M.A., Eder, K.J., Werner, I., Hedrick, R.P. Environ. Toxicol. Chem. (2005) [Pubmed]
  13. The synergism of nucleoside antibiotics combined with guanine 7-N-oxide against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV). Hasobe, M., Saneyoshi, M., Isono, K. J. Antibiot. (1986) [Pubmed]
  14. Rescue of synthetic salmonid rhabdovirus minigenomes. Biacchesi, S., Yu, Y.X., Béarzotti, M., Tafalla, C., Fernandez-Alonso, M., Brémont, M. J. Gen. Virol. (2000) [Pubmed]
  15. Distribution and variation of NV genes in fish rhabdoviruses. Kurath, G., Higman, K.H., Björklund, H.V. J. Gen. Virol. (1997) [Pubmed]
  16. Interferon mediated antiviral activity against salmonid fish viruses in BF-2 and other cell lines. Saint-Jean, S.R., Pérez-Prieto, S.I. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  17. The glycoprotein of a fish rhabdovirus profiles the virus-specific T-cell repertoire in rainbow trout. Boudinot, P., Bernard, D., Boubekeur, S., Thoulouze, M.I., Bremont, M., Benmansour, A. J. Gen. Virol. (2004) [Pubmed]
  18. Viral susceptibility of newly established cell lines from the Hawaiian monk seal Monachus schauinslandi. Lu, Y., Aguirre, A.A., Wang, Y., Zeng, L., Loh, P.C., Yanagihara, R. Dis. Aquat. Org. (2003) [Pubmed]
  19. Molecular epizootiology and evolution of the glycoprotein and non-virion protein genes of infectious hematopoietic necrosis virus, a fish rhabdovirus. Nichol, S.T., Rowe, J.E., Winton, J.R. Virus Res. (1995) [Pubmed]
  20. Evaluation of the protective immunogenicity of the N, P, M, NV and G proteins of infectious hematopoietic necrosis virus in rainbow trout oncorhynchus mykiss using DNA vaccines. Corbeil, S., Lapatra, S.E., Anderson, E.D., Jones, J., Vincent, B., Hsu, Y.L., Kurath, G. Dis. Aquat. Org. (1999) [Pubmed]
  21. Identification of the non-virion (NV) protein of fish rhabdoviruses viral haemorrhagic septicaemia virus and infectious haematopoietic necrosis virus. Schütze, H., Enzmann, P.J., Mundt, E., Mettenleiter, T.C. J. Gen. Virol. (1996) [Pubmed]
  22. Nucleotide sequence of the 2 matrix protein genes (M1 and M2) of hirame rhabdovirus (HRV), a fish rhabdovirus. Nishizawa, T., Kurath, G., Winton, J.R. Vet. Res. (1995) [Pubmed]
  23. The NV genes of fish rhabdoviruses: development of RNase protection assays for rapid assessment of genetic variation. Kurath, G., Higman, K.H., Björklund, H.V. Vet. Res. (1995) [Pubmed]
  24. Mother to fry, successful transfer of immunity against infectious haematopoietic necrosis virus infection in rainbow trout. Oshima, S., Hata, J., Segawa, C., Yamashita, S. J. Gen. Virol. (1996) [Pubmed]
  25. Characterization of the mutant spectra of a fish RNA virus within individual hosts during natural infections. Emmenegger, E.J., Troyer, R.M., Kurath, G. Virus Res. (2003) [Pubmed]
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