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Gene Review: 

cma2  -  cyclopropane-fatty-acyl-phospholipid synthase

Mycobacterium tuberculosis CDC1551

 
 
 
 
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Disease relevance of cma2

  • Expression of cma2 in Mycobacterium smegmatis resulted in the cyclopropanation of the proximal double bond in the alpha 1 series of mycolic acids [1].
 

High impact information on cma2

  • This gene, named cma2, was sequenced and found to be 52% identical to cma1 (which cyclopropanates the distal double bond) and 73% identical to the gene from M. leprae [1].

References

  1. The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2. George, K.M., Yuan, Y., Sherman, D.R., Barry, C.E. J. Biol. Chem. (1995) [Pubmed]
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