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Gene Review

cma1  -  cyclopropane-fatty-acyl-phospholipid synthase

Mycobacterium tuberculosis CDC1551

 
 
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Disease relevance of cma1

 

High impact information on cma1

  • Using the gene for the enzyme that introduces the distal cyclopropane (cma1) as a probe, we have cloned and sequenced a cluster of genes coding for four highly homologous methyl transferases (mma1-4) [2].
  • M. smegmatis overexpressing the cma1 gene product significantly resist killing by hydrogen peroxide, suggesting that this modification may be an important adaptation of slow-growing mycobacteria to oxidative stress [1].
  • This gene, named cma2, was sequenced and found to be 52% identical to cma1 (which cyclopropanates the distal double bond) and 73% identical to the gene from M. leprae [3].

References

 
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