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Gene Review:

MS4A3 - membrane-spanning 4-domains, subfamily A,...

Homo sapiens

Synonyms: CD20 antigen-like protein, CD20L, HTM4, HTm4, Hematopoietic-specific transmembrane protein 4, ...

Donato, J.L. et al., Chinami, M. et al., Liang, Y. et al., Adra, C.N. et al.

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High impact information on MS4A3

Our data indicate that HTm4 is expressed in hematopoietic tissues and is tightly regulated during the differentiation of hematopoietic stem cells [1].
Overexpression of HTm4 can cause cell cycle arrest at the G(0)/G(1) phase [1].
Using fluorescence in situ hybridization, we localized HTm4 to human chromosome 11q12-13.1, where the CD20 and Fc epsilon RI beta genes are also located [2].
Here, we present in vitro data showing the direct interaction between the HTm4 C terminus and KAP Tyr141 [3].
CD20, the high-affinity IgE receptor beta chain (FcepsilonRIbeta), and HTm4 are structurally related cell surface proteins expressed by hematopoietic cells [4].

Anatomical context of MS4A3

We have reported that KAP is bound and activated by a nuclear membrane protein, HTm4 [3].

Other interactions of MS4A3

Human HTm4 is a hematopoietic cell cycle regulator [1].

References

Human HTm4 is a hematopoietic cell cycle regulator. Donato, J.L., Ko, J., Kutok, J.L., Cheng, T., Shirakawa, T., Mao, X.Q., Beach, D., Scadden, D.T., Sayegh, M.H., Adra, C.N. J. Clin. Invest. (2002) [Pubmed]
Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions. Adra, C.N., Lelias, J.M., Kobayashi, H., Kaghad, M., Morrison, P., Rowley, J.D., Lim, B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. Chinami, M., Yano, Y., Yang, X., Salahuddin, S., Moriyama, K., Shiroishi, M., Turner, H., Shirakawa, T., Adra, C.N. J. Biol. Chem. (2005) [Pubmed]
Structural organization of the human MS4A gene cluster on Chromosome 11q12. Liang, Y., Buckley, T.R., Tu, L., Langdon, S.D., Tedder, T.F. Immunogenetics (2001) [Pubmed]

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