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Gene Review

pbp2a  -  penicillin-binding protein 2A

Streptococcus pneumoniae R6

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Disease relevance of pbp2a

  • All six penicillin-binding protein (PBP) genes, namely, pbp1a, pbp1b, pbp2a, pbp2b, pbp2x, and pbp3, of 40 Streptococcus pneumoniae clinical isolates, including penicillin-resistant S. pneumoniae isolates collected in Japan, were completely sequenced [1].
  • To facilitate our structural studies of PBPs, we constructed a 5'-truncated version (lacking bp from 1 to 231 encoding the N-terminal part of the protein including the transmembrane domain) of the pbp2a gene of Streptococcus pneumoniae and expressed the truncated gene product as a GST fusion protein in Escherichia coli [2].

High impact information on pbp2a


  1. Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan. Sanbongi, Y., Ida, T., Ishikawa, M., Osaki, Y., Kataoka, H., Suzuki, T., Kondo, K., Ohsawa, F., Yonezawa, M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  2. Penicillin-binding protein 2a of Streptococcus pneumoniae: expression in Escherichia coli and purification and refolding of inclusion bodies into a soluble and enzymatically active enzyme. Zhao, G., Meier, T.I., Hoskins, J., Jaskunas, S.R. Protein Expr. Purif. (1999) [Pubmed]
  3. The glycosyltransferase domain of penicillin-binding protein 2a from Streptococcus pneumoniae catalyzes the polymerization of murein glycan chains. Di Guilmi, A.M., Dessen, A., Dideberg, O., Vernet, T. J. Bacteriol. (2003) [Pubmed]
  4. Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae. Hoskins, J., Matsushima, P., Mullen, D.L., Tang, J., Zhao, G., Meier, T.I., Nicas, T.I., Jaskunas, S.R. J. Bacteriol. (1999) [Pubmed]
  5. Mutational analysis of the Streptococcus pneumoniae bimodular class A penicillin-binding proteins. Paik, J., Kern, I., Lurz, R., Hakenbeck, R. J. Bacteriol. (1999) [Pubmed]
  6. Analysis of penicillin-binding protein lb and 2a genes from Streptococcus pneumoniae. Du Plessis, M., Smith, A.M., Klugman, K.P. Microb. Drug Resist. (2000) [Pubmed]
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