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Chemical Compound Review

Flavomycin     (2S,3S,4R,5R,6R)-5- [(2S,3R,4R,5S,6R)-3...

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Disease relevance of Flavomycin


High impact information on Flavomycin

  • Consistent with this suggestion, we found that non-glycopeptide inhibitors of the late steps in cell wall biosynthesis such as moenomycin A, bacitracin and ramoplanin were not inducers of the S. coelicolor VanRS system, in contrast to results obtained in enterococcal VanRS systems [6].
  • We report here the total synthesis of moenomycin A using the sulfoxide glycosylation method [7].
  • Antibiotics that acted as inducers of the sigE signal transduction system were all inhibitors of intermediate and late steps in peptidoglycan biosynthesis, including ramoplanin, moenomycin A, bacitracin, several glycopeptides and some beta-lactams [8].
  • MGT activity was inhibited by moenomycin A, and the reaction product was sensitive to lysozyme treatment [9].
  • The pbp2a mutants, but not the other mutants, were more sensitive to moenomycin, a transglycosylase inhibitor [10].

Chemical compound and disease context of Flavomycin


Biological context of Flavomycin


Anatomical context of Flavomycin

  • Moenomycin A is the only known natural antibiotic that inhibits bacterial cell wall synthesis by binding to the transglycosylases that catalyze formation of the carbohydrate chains of peptidoglycan [7].
  • Characterisation of antibiotic moenomycin A interaction with phospholipid model membranes [16].
  • Influence of flavomycin on microbial numbers, microbial metabolism and gut tissue protein turnover in the digestive tract of sheep [12].

Gene context of Flavomycin


Analytical, diagnostic and therapeutic context of Flavomycin


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