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Gene Review:

sodA - superoxide dismutase

Streptococcus pneumoniae R6

Kawamura, Y. et al., Arbique, J.C. et al.

Arbique, Poyart, Trieu-Cuot, Quesne, Carvalho, Steigerwalt, Morey, Jackson, Davidson, Facklam, Kawamura, Whiley, Shu, Ezaki, Hardie,

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Disease relevance of sodA

Genetic tests for pneumolysin (ply) and manganese-dependent superoxide dismutase (sodA) and identification tests with a commercial probe, AccuProbe Pneumococcus, do not discriminate between the new species and S. pneumoniae [1].
The Streptococcus pneumoniae sub-cluster was located within the Streptococcus mitis cluster, but the sodA gene of S. pneumoniae was very conserved and therefore could be separated from all other species examined [2].

Analytical, diagnostic and therapeutic context of sodA

We conclude that the partial sequence analysis of the sodA gene could be applied globally as a reliable and easy method for the accurate identification of all species currently within the mitis group [2].

References

Accuracy of phenotypic and genotypic testing for identification of Streptococcus pneumoniae and description of Streptococcus pseudopneumoniae sp. nov. Arbique, J.C., Poyart, C., Trieu-Cuot, P., Quesne, G., Carvalho, M.d.a. .G., Steigerwalt, A.G., Morey, R.E., Jackson, D., Davidson, R.J., Facklam, R.R. J. Clin. Microbiol. (2004) [Pubmed]
Genetic approaches to the identification of the mitis group within the genus Streptococcus. Kawamura, Y., Whiley, R.A., Shu, S.E., Ezaki, T., Hardie, J.M. Microbiology (Reading, Engl.) (1999) [Pubmed]

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