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Chemical Compound Review

Manganese-52     manganese

Synonyms: AC1L3GKQ, Manganese, isotope of mass 52
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Disease relevance of manganese


Psychiatry related information on manganese


High impact information on manganese


Chemical compound and disease context of manganese


Biological context of manganese

  • We now report the structure of IPNS complexed with manganese, which reveals the active site is unusually buried within a 'jelly-roll' motif and lined by hydrophobic residues, and suggest how this structure permits the process of penicillin formation [19].
  • Here we report that when calcium influx is blocked by cobalt or manganese ions in a calcium-free Ringer, as measured with Fura-2, and [Ca2+]i is elevated by liberation from a caged calcium compound, transmitter release at the crayfish neuromuscular junction is unaffected by presynaptic action potentials [20].
  • A key step in dioxygen evolution during photosynthesis is the oxidative generation of the O-O bond from water by a manganese cluster consisting of M2(mu-O)2 units (where M is manganese) [21].
  • In the photosynthetic evolution of oxygen, water oxidation occurs at a catalytic site that includes four manganese atoms together with the essential cofactors, the calcium and chlorine ions [1].
  • Inhibition of reverse transcription in vivo by elevated manganese ion concentration [22].

Anatomical context of manganese

  • Data from oriented membranes display distinct dichroism, precluding highly symmetrical structures for the manganese complex [1].
  • We present the results of experiments simultaneously tracing manganese chloride and wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) to evaluate the specificity of the former by tracing the neuronal connections of the basal ganglia of the monkey [23].
  • Polyacrylamide electrophoresis separated this activity into a minor band that appeared to be the manganese-containing superoxide dismutase associated with mitochondria and a more concentrated, cyanide-sensitive, cytosol form of the enzyme with electrophoretic mobility that corresponded to that of erythrocyte cuprozinc superoxide dismutase [24].
  • In the current study, we show that IL-1beta induces destruction of INS-1 insulinoma cells, while having no effect on a second insulinoma cell line RIN1046-38 and its engineered derivatives, and that this difference is correlated with a higher level of expression of manganese superoxide dismutase (MnSOD) in the latter cells [25].
  • Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement [26].

Associations of manganese with other chemical compounds


Gene context of manganese


Analytical, diagnostic and therapeutic context of manganese


  1. Where plants make oxygen: a structural model for the photosynthetic oxygen-evolving manganese cluster. Yachandra, V.K., DeRose, V.J., Latimer, M.J., Mukerji, I., Sauer, K., Klein, M.P. Science (1993) [Pubmed]
  2. Manganese superoxide dismutase as a target of autoantibodies in acute Epstein-Barr virus infection. Ritter, K., Kühl, R.J., Semrau, F., Eiffert, H., Kratzin, H.D., Thomssen, R. J. Exp. Med. (1994) [Pubmed]
  3. Pertussis toxin treatment alters manganese superoxide dismutase activity in lung. Evidence for lung oxygen toxicity in air-breathing rats. Clerch, L.B., Neithardt, G., Spencer, U., Melendez, J.A., Massaro, G.D., Massaro, D. J. Clin. Invest. (1994) [Pubmed]
  4. Induction of manganese superoxide dismutase in rat cardiac myocytes increases tolerance to hypoxia 24 hours after preconditioning. Yamashita, N., Nishida, M., Hoshida, S., Kuzuya, T., Hori, M., Taniguchi, N., Kamada, T., Tada, M. J. Clin. Invest. (1994) [Pubmed]
  5. Tumorigenic effect of an organomanganese compound on F344 rats and Swiss albino mice. Furst, A. J. Natl. Cancer Inst. (1978) [Pubmed]
  6. Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group. Dexter, D.T., Jenner, P., Schapira, A.H., Marsden, C.D. Ann. Neurol. (1992) [Pubmed]
  7. Elevated manganese levels associated with dementia and extrapyramidal signs. Banta, R.G., Markesbery, W.R. Neurology (1977) [Pubmed]
  8. Manganese accentuates adverse mental health effects associated with alcohol use disorders. Sassine, M.P., Mergler, D., Bowler, R., Hudnell, H.K. Biol. Psychiatry (2002) [Pubmed]
  9. Erythrocyte manganese concentration in healthy Japanese children, adults, and the elderly, and in cord blood. Hatano, S., Nishi, Y., Usui, T. Am. J. Clin. Nutr. (1983) [Pubmed]
  10. With the help of giants. Fridovich, I. Annu. Rev. Biochem. (2003) [Pubmed]
  11. Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes. Christianson, D.W., Cox, J.D. Annu. Rev. Biochem. (1999) [Pubmed]
  12. The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. Borgstahl, G.E., Parge, H.E., Hickey, M.J., Beyer, W.F., Hallewell, R.A., Tainer, J.A. Cell (1992) [Pubmed]
  13. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nishikawa, T., Edelstein, D., Du, X.L., Yamagishi, S., Matsumura, T., Kaneda, Y., Yorek, M.A., Beebe, D., Oates, P.J., Hammes, H.P., Giardino, I., Brownlee, M. Nature (2000) [Pubmed]
  14. Induction and immunolocalization of manganese superoxide dismutase in acute acetic acid-induced colitis in the rat. Tannahill, C.L., Stevenot, S.A., Campbell-Thompson, M., Nick, H.S., Valentine, J.F. Gastroenterology (1995) [Pubmed]
  15. Roles of manganese and iron in the regulation of the biosynthesis of manganese-superoxide dismutase in Escherichia coli. Hassan, H.M., Schrum, L.W. FEMS Microbiol. Rev. (1994) [Pubmed]
  16. Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases. Aoyama, K., Matsubara, K., Fujikawa, Y., Nagahiro, Y., Shimizu, K., Umegae, N., Hayase, N., Shiono, H., Kobayashi, S. Ann. Neurol. (2000) [Pubmed]
  17. Brain superoxide dismutase, catalase, and glutathione peroxidase activities in amyotrophic lateral sclerosis. Przedborski, S., Donaldson, D., Jakowec, M., Kish, S.J., Guttman, M., Rosoklija, G., Hays, A.P. Ann. Neurol. (1996) [Pubmed]
  18. Effects of manganese on carcinogenicity and metabolism of nickel subsulfide. Sunderman, F.W., Kasprzak, K.S., Lau, T.J., Minghetti, P.P., Maenza, R.M., Becker, N., Onkelinx, C., Goldblatt, P.J. Cancer Res. (1976) [Pubmed]
  19. Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Roach, P.L., Clifton, I.J., Fülöp, V., Harlos, K., Barton, G.J., Hajdu, J., Andersson, I., Schofield, C.J., Baldwin, J.E. Nature (1995) [Pubmed]
  20. Action potentials must admit calcium to evoke transmitter release. Mulkey, R.M., Zucker, R.S. Nature (1991) [Pubmed]
  21. Reversible cleavage and formation of the dioxygen O-O bond within a dicopper complex. Halfen, J.A., Mahapatra, S., Wilkinson, E.C., Kaderli, S., Young, V.G., Que, L., Zuberbühler, A.D., Tolman, W.B. Science (1996) [Pubmed]
  22. Inhibition of reverse transcription in vivo by elevated manganese ion concentration. Bolton, E.C., Mildvan, A.S., Boeke, J.D. Mol. Cell (2002) [Pubmed]
  23. Magnetic resonance imaging of neuronal connections in the macaque monkey. Saleem, K.S., Pauls, J.M., Augath, M., Trinath, T., Prause, B.A., Hashikawa, T., Logothetis, N.K. Neuron (2002) [Pubmed]
  24. The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. Johnston, R.B., Keele, B.B., Misra, H.P., Lehmeyer, J.E., Webb, L.S., Baehner, R.L., RaJagopalan, K.V. J. Clin. Invest. (1975) [Pubmed]
  25. Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. Hohmeier, H.E., Thigpen, A., Tran, V.V., Davis, R., Newgard, C.B. J. Clin. Invest. (1998) [Pubmed]
  26. Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement. Curnutte, J.T., Karnovsky, M.L., Babior, B.M. J. Clin. Invest. (1976) [Pubmed]
  27. Cytidine 3',5'-monophosphate (cyclic CMP) formation in mammalian tissues. Cech, S.Y., Ignarro, L.J. Science (1977) [Pubmed]
  28. Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. Derbyshire, V., Freemont, P.S., Sanderson, M.R., Beese, L., Friedman, J.M., Joyce, C.M., Steitz, T.A. Science (1988) [Pubmed]
  29. Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis. Rahman, S.H., Ibrahim, K., Larvin, M., Kingsnorth, A., McMahon, M.J. Gastroenterology (2004) [Pubmed]
  30. Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins. Hettema, E.H., Valdez-Taubas, J., Pelham, H.R. EMBO J. (2004) [Pubmed]
  31. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Supek, F., Supekova, L., Nelson, H., Nelson, N. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  32. Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family. Luk, E., Carroll, M., Baker, M., Culotta, V.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  33. Suppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles. Lin, S.J., Culotta, V.C. Mol. Cell. Biol. (1996) [Pubmed]
  34. Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. Behrend, L., Mohr, A., Dick, T., Zwacka, R.M. Mol. Cell. Biol. (2005) [Pubmed]
  35. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. Leib, S.L., Kim, Y.S., Chow, L.L., Sheldon, R.A., Täuber, M.G. J. Clin. Invest. (1996) [Pubmed]
  36. Cellular mechanisms mediating rat renal microvascular constriction by angiotensin II. Takenaka, T., Suzuki, H., Fujiwara, K., Kanno, Y., Ohno, Y., Hayashi, K., Nagahama, T., Saruta, T. J. Clin. Invest. (1997) [Pubmed]
  37. Enzyme-linked immunosorbent assay for human manganese-containing superoxide dismutase and its content in lung cancer. Iizuka, S., Taniguchi, N., Makita, A. J. Natl. Cancer Inst. (1984) [Pubmed]
  38. Manganese toxicity in children receiving long-term parenteral nutrition. Fell, J.M., Reynolds, A.P., Meadows, N., Khan, K., Long, S.G., Quaghebeur, G., Taylor, W.J., Milla, P.J. Lancet (1996) [Pubmed]
  39. Dystonia, hyperintense basal ganglia, and high whole blood manganese levels in Alagille's syndrome. Devenyi, A.G., Barron, T.F., Mamourian, A.C. Gastroenterology (1994) [Pubmed]
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