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Gene Review

NRXN3  -  neurexin 3

Homo sapiens

Synonyms: KIAA0743
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High impact information on NRXN3

  • Unexpectedly, two of these, NRXN1 ( approximately 1.1 Mb) and NRXN3 ( approximately 1.7 Mb), are among the largest known human genes [1].
  • Neurexins are synaptic adhesion proteins encoded by 3 genes (NRXN1, NRXN2, and NRXN3) each transcribed from 2 promoters to yield longer (alpha) and shorter (beta) forms [2].
  • Cardiac isoforms of NRXN3 probably participate in a complex involving dystroglycan and proteins of extracellular matrix, involved in intercellular connections [3].
  • We reported here on the expression of NRXN3 in additional tissues (lung, pancreas, heart, placenta, liver, and kidney) and on the identification and characterization of heart-specific splicing variants of NRXN3 [3].


  1. Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. Rowen, L., Young, J., Birditt, B., Kaur, A., Madan, A., Philipps, D.L., Qin, S., Minx, P., Wilson, R.K., Hood, L., Graveley, B.R. Genomics (2002) [Pubmed]
  2. Ca(2+)-dependent splicing of neurexin IIalpha. Rozic-Kotliroff, G., Zisapel, N. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  3. Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3). Occhi, G., Rampazzo, A., Beffagna, G., Antonio Danieli, G. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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