Gene Review:
ECM1 - extracellular matrix protein 1
Homo sapiens
Synonyms:
Extracellular matrix protein 1, Secretory component p85
Candia,
Griffith,
Orlando,
Heaphy,
Hines,
Hirata,
Morita,
Nagakura,
Uchida,
Fujisawa,
Tsujii,
Takino,
Sato,
Yamada,
Miyamori,
Yoshioka,
Rot,
von Andrian,
Assoian,
Schwartz,
Aarden,
Alblas,
Nijweide,
Mackie,
van der Plas,
Helfrich,
Horton,
Schwartz,
Assoian,
Aplin,
Howe,
Juliano,
Pribila,
Quale,
Mueller,
Shimizu,
Natividad,
Burton,
Holland,
Joof,
Kwiatkowski,
Mabey,
Bailey,
Cooke,
Rockett,
Blobel,
Garlanda,
Bastone,
Bottazzi,
Mantovani,
Andrei Drabovich,
Urso,
Scrimgeour,
Clarkson,
Thompson,
Chen,
Kjaer,
Lind,
Sundfeldt And,
Dahm-K??hler,
Weijdeg??rd,
Br??nnstr??m,
- Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma. Drabovich, A.P., Dimitromanolakis, A., Saraon, P., Soosaipillai, A., Batruch, I., Mullen, B., Jarvi, K., Diamandis, E.P. Sci. Transl. Med. (2013)
- Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay. Drabovich, A.P., Jarvi, K., Diamandis, E.P. Mol. Cell. Proteomics. (2011)
- Extracellular matrix protein 1 (ECM1) is over-expressed in malignant epithelial tumors. Wang, L., Yu, J., Ni, J., Xu, X.M., Wang, J., Ning, H., Pei, X.F., Chen, J., Yang, S., Underhill, C.B., Liu, L., Liekens, J., Merregaert, J., Zhang, L. Cancer Lett. (2003)
- Extracellular matrix turnover and disease severity in Anderson-Fabry disease. Shah, J.S., Hughes, D.A., Tayebjee, M.H., MacFadyen, R.J., Mehta, A.B., Elliott, P.M. Journal of inherited metabolic disease (2007)
- Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines. Weber, C.K., Sommer, G., Michl, P., Fensterer, H., Weimer, M., Gansauge, F., Leder, G., Adler, G., Gress, T.M. Gastroenterology (2001)
- Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome. Bergamaschi, A., Tagliabue, E., Sørlie, T., Naume, B., Triulzi, T., Orlandi, R., Russnes, H.G., Nesland, J.M., Tammi, R., Auvinen, P., Kosma, V.M., Ménard, S., Børresen-Dale, A.L. J. Pathol. (2008)
- The angiopathy of subcortical arteriosclerotic encephalopathy (Binswanger's disease): immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. Zhang, W.W., Olsson, Y. Acta Neuropathol. (1997)
- Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Kjaer, M. Physiol. Rev. (2004)
- Remarkable roles of proteolysis on and beyond the cell surface. Blobel, C.P. Curr. Opin. Cell Biol. (2000)
- Cell adhesion molecules, signal transduction and cell growth. Aplin, A.E., Howe, A.K., Juliano, R.L. Curr. Opin. Cell Biol. (1999)
- The superfamily of proteins with von Willebrand factor type A-like domains: one theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms. Colombatti, A., Bonaldo, P. Blood (1991)
- Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Garlanda, C., Bottazzi, B., Bastone, A., Mantovani, A. Annu. Rev. Immunol. (2005)
- Integrins and T cell-mediated immunity. Pribila, J.T., Quale, A.C., Mueller, K.L., Shimizu, Y. Annu. Rev. Immunol. (2004)
- Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Rot, A., von Andrian, U.H. Annu. Rev. Immunol. (2004)
- IL-13 effector functions. Wynn, T.A. Annu. Rev. Immunol. (2003)
- Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Dustin, M.L., Springer, T.A. Annu. Rev. Immunol. (1991)
- German cockroach proteases regulate matrix metalloproteinase-9 in human bronchial epithelial cells. Page, K., Hughes, V.S., Bennett, G.W., Wong, H.R. Allergy (2006)
- Protease nexin-1 expression is altered in human breast cancer. Candia, B.J., Hines, W.C., Heaphy, C.M., Griffith, J.K., Orlando, R.A. Cancer Cell Int. (2006)
- Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Oyama, N., Chan, I., Neill, S.M., South, A.P., Wojnarowska, F., Kawakami, Y., D'Cruz, D., Mepani, K., Hughes, G.J., Bhogal, B.S., Kaneko, F., Black, M.M., McGrath, J.A. J. Clin. Invest. (2004)
- Relationship between matrix metalloproteinases MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinases-1 and IL-5, IL-8 in nasal polyps. Chen, Y.S., Langhammer, T., Westhofen, M., Lorenzen, J. Allergy (2007)
- Immunohistochemical expression of cathepsin D in correlation with extracellular matrix component, steroid receptor status and proliferative indices in breast cancer. Ioachim, E., Kamina, S., Kontostolis, M., Agnantis, N.J. Virchows Arch. (1997)
- Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). Hamada, T., McLean, W.H., Ramsay, M., Ashton, G.H., Nanda, A., Jenkins, T., Edelstein, I., South, A.P., Bleck, O., Wessagowit, V., Mallipeddi, R., Orchard, G.E., Wan, H., Dopping-Hepenstal, P.J., Mellerio, J.E., Whittock, N.V., Munro, C.S., van Steensel, M.A., Steijlen, P.M., Ni, J., Zhang, L., Hashimoto, T., Eady, R.A., McGrath, J.A. Hum. Mol. Genet. (2002)
- Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation. Hamada, T., Wessagowit, V., South, A.P., Ashton, G.H., Chan, I., Oyama, N., Siriwattana, A., Jewhasuchin, P., Charuwichitratana, S., Thappa, D.M., Jeevankumar, B., Lenane, P., Krafchik, B., Kulthanan, K., Shimizu, H., Kaya, T.I., Erdal, M.E., Paradisi, M., Paller, A.S., Seishima, M., Hashimoto, T., McGrath, J.A. J. Invest. Dermatol. (2003)
- The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization. Smits, P., Ni, J., Feng, P., Wauters, J., Van Hul, W., Boutaibi, M.E., Dillon, P.J., Merregaert, J. Genomics (1997)
- Distribution of hyaluronan during extracellular matrix remodeling in human restenotic arteries and balloon-injured rat carotid arteries. Riessen, R., Wight, T.N., Pastore, C., Henley, C., Isner, J.M. Circulation (1996)
- Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Fearon, U., Mullan, R., Markham, T., Connolly, M., Sullivan, S., Poole, A.R., Fitzgerald, O., Bresnihan, B., Veale, D.J. Arthritis Rheum. (2006)
- Differentiation-dependent alternative splicing and expression of the extracellular matrix protein 1 gene in human keratinocytes. Smits, P., Poumay, Y., Karperien, M., Tylzanowski, P., Wauters, J., Huylebroeck, D., Ponec, M., Merregaert, J. J. Invest. Dermatol. (2000)
- The relationship of VEGF and PGE2 expression to extracellular matrix remodelling of the tenosynovium in the carpal tunnel syndrome. Hirata, H., Nagakura, T., Tsujii, M., Morita, A., Fujisawa, K., Uchida, A. J. Pathol. (2004)
- Effects of rhDecorin on TGF-beta1 induced human hepatic stellate cells LX-2 activation. Shi, Y.F., Zhang, Q., Cheung, P.Y., Shi, L., Fong, C.C., Zhang, Y., Tzang, C.H., Chan, B.P., Fong, W.F., Chun, J., Kung, H.F., Yang, M. Biochim. Biophys. Acta (2006)
- Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Assoian, R.K., Schwartz, M.A. Curr. Opin. Genet. Dev. (2001)
- Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. Zhou, X., Murphy, F.R., Gehdu, N., Zhang, J., Iredale, J.P., Benyon, R.C. J. Biol. Chem. (2004)
- Beta-1-integrin expression in adult acute lymphoblastic leukemia: possible relationship with the stem cell antigen CD34. Cacciola, R.R., Stagno, F., Impera, S., Assisi, A.R., Cacciola, E., Guglielmo, P. Acta Haematol. (1997)
- TNF-alpha induction of CD44-mediated leukocyte adhesion by sulfation. Maiti, A., Maki, G., Johnson, P. Science (1998)
- Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. Saharinen, J., Taipale, J., Keski-Oja, J. EMBO J. (1996)
- VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. Poltorak, Z., Cohen, T., Sivan, R., Kandelis, Y., Spira, G., Vlodavsky, I., Keshet, E., Neufeld, G. J. Biol. Chem. (1997)
- Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin. Hayashido, Y., Lucas, A., Rougeot, C., Godyna, S., Argraves, W.S., Rochefort, H. Int. J. Cancer (1998)
- Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2. Toth, M., Bernardo, M.M., Gervasi, D.C., Soloway, P.D., Wang, Z., Bigg, H.F., Overall, C.M., DeClerck, Y.A., Tschesche, H., Cher, M.L., Brown, S., Mobashery, S., Fridman, R. J. Biol. Chem. (2000)
- A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. Takino, T., Yoshioka, K., Miyamori, H., Yamada, K.M., Sato, H. Oncogene (2002)
- Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network. Leighton, M., Kadler, K.E. J. Biol. Chem. (2003)
- ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage. Roy, R., Wewer, U.M., Zurakowski, D., Pories, S.E., Moses, M.A. J. Biol. Chem. (2004)
- Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor. Park, H.I., Ni, J., Gerkema, F.E., Liu, D., Belozerov, V.E., Sang, Q.X. J. Biol. Chem. (2000)
- Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin. Ghert, M.A., Qi, W.N., Erickson, H.P., Block, J.A., Scully, S.P. Cell Struct. Funct. (2001)
- The receptor for urokinase-type plasminogen activator regulates fibronectin matrix assembly in human skin fibroblasts. Monaghan, E., Gueorguiev, V., Wilkins-Port, C., McKeown-Longo, P.J. J. Biol. Chem. (2004)
- Adhesive properties of isolated chick osteocytes in vitro. Aarden, E.M., Nijweide, P.J., van der Plas, A., Alblas, M.J., Mackie, E.J., Horton, M.A., Helfrich, M.H. Bone (1996)
- A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection. Natividad, A., Cooke, G., Holland, M.J., Burton, M.J., Joof, H.M., Rockett, K., Kwiatkowski, D.P., Mabey, D.C., Bailey, R.L. BMC Med. Genet. (2006)
- Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts. Arnott, J.A., Nuglozeh, E., Rico, M.C., Arango-Hisijara, I., Odgren, P.R., Safadi, F.F., Popoff, S.N. J. Cell. Physiol. (2007)
- Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. Schwartz, M.A., Assoian, R.K. J. Cell. Sci. (2001)
- Group A Streptococcus tissue invasion by CD44-mediated cell signalling. Cywes, C., Wessels, M.R. Nature (2001)
- ICAM-3 regulates lymphocyte morphology and integrin-mediated T cell interaction with endothelial cell and extracellular matrix ligands. Campanero, M.R., Sánchez-Mateos, P., del Pozo, M.A., Sánchez-Madrid, F. J. Cell Biol. (1994)
- Gelatinases and their tissue inhibitors during human ovulation: increased expression of tissue inhibitor of matrix metalloproteinase-1. Lind, A.K., Dahm-K??hler, P., Weijdeg??rd, B., Sundfeldt And, K., Br??nnstr??m, M. Mol. Hum. Reprod. (2006)
- Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) Cells by isoflavones. Puli, S., Lai, J.C., Bhushan, A. J. Neurooncol. (2006)
- Carboxylated chitooligosaccharides (CCOS) inhibit MMP-9 expression in human fibrosarcoma cells via down-regulation of AP-1. Rajapakse, N., Kim, M.M., Mendis, E., Huang, R., Kim, S.K. Biochim. Biophys. Acta (2006)
- PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules. Furukawa, K., Kumon, Y., Harada, H., Kohno, S., Nagato, S., Teraoka, M., Fujiwara, S., Nakagawa, K., Hamada, K., Ohnishi, T. Int. J. Oncol. (2006)
- Effects of hypoxia and reoxygenation on the expression levels of the urokinase-type plasminogen activator, its inhibitor plasminogen activator inhibitor type-1 and the urokinase-type plasminogen activator receptor in human head and neck tumour cells. Sprague, L.D., Tomaso, H., Mengele, K., Schilling, D., Bayer, C., Stadler, P., Schmitt, M., Molls, M. Oncol. Rep. (2007)
- Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21. Johnson, M.R., Wilkin, D.J., Vos, H.L., Ortiz de Luna, R.I., Dehejia, A.M., Polymeropoulos, M.H., Francomano, C.A. Matrix Biol. (1997)
- Analysis of human skeletal muscle after 48 h immobilization reveals alterations in mRNA and protein for extracellular matrix components. Urso, M.L., Scrimgeour, A.G., Chen, Y.W., Thompson, P.D., Clarkson, P.M. J. Appl. Physiol. (2006)
- Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells. Han, Z., Ni, J., Smits, P., Underhill, C.B., Xie, B., Chen, Y., Liu, N., Tylzanowski, P., Parmelee, D., Feng, P., Ding, I., Gao, F., Gentz, R., Huylebroeck, D., Merregaert, J., Zhang, L. FASEB J. (2001)