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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TTYH2  -  tweety family member 2

Homo sapiens

Synonyms: C17orf29, Protein tweety homolog 2, hTTY2
 
 
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Disease relevance of TTYH2

  • In addition to a putative role in brain and testis, the over-expression of TTYH2 in renal cell carcinoma suggests that it may have an important role in kidney tumorigenesis [1].
 

High impact information on TTYH2

  • Similarly, hTTYH2 encoded an ionomycin-induced maxi-Cl(-) channel, but TTYH1 encoded a Ca(2+)-independent and swelling-activated maxi-Cl(-) channel [2].

References

  1. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. Rae, F.K., Hooper, J.D., Eyre, H.J., Sutherland, G.R., Nicol, D.L., Clements, J.A. Genomics (2001) [Pubmed]
  2. A novel human Cl(-) channel family related to Drosophila flightless locus. Suzuki, M., Mizuno, A. J. Biol. Chem. (2004) [Pubmed]
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