Chemical Compound Review:
ionomycin (4R,6S,8S,10Z,12R,14S,16E,18R, 19R,20S,21S)...
Synonyms:
LS-84162, AC1O5I4S, 56092-81-0
- Ionomycin stimulates mast cell histamine secretion by forming a lipid-soluble calcium complex. Bennett, J.P., Cockcroft, S., Gomperts, B.D. Nature (1979)
- Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I. Siekevitz, M., Josephs, S.F., Dukovich, M., Peffer, N., Wong-Staal, F., Greene, W.C. Science (1987)
- Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. Jin, Y., Knudsen, E., Wang, L., Bryceson, Y., Damaj, B., Gessani, S., Maghazachi, A.A. Blood (2003)
- Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus. Zoeteweij, J.P., Moses, A.V., Rinderknecht, A.S., Davis, D.A., Overwijk, W.W., Yarchoan, R., Orenstein, J.M., Blauvelt, A. Blood (2001)
- Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. Miranti, C.K., Ginty, D.D., Huang, G., Chatila, T., Greenberg, M.E. Mol. Cell. Biol. (1995)
- Calcium ion transients in neutrophils from patients with sporadic Alzheimer's disease. Garlind, A., Nilsson, E., Palmblad, J. Neurosci. Lett. (1998)
- Effects of Ca2+ on erythrocyte membrane skeleton-bound phosphofructokinase, ATP levels, and hemolysis. Assouline-Cohen, M., Beitner, R. Mol. Genet. Metab. (1999)
- Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Ruland, J., Duncan, G.S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D.G., Bouchard, D., Wakeham, A., Ohashi, P.S., Mak, T.W. Cell (2001)
- An immunodeficiency characterized by defective signal transduction in T lymphocytes. Chatila, T., Wong, R., Young, M., Miller, R., Terhorst, C., Geha, R.S. N. Engl. J. Med. (1989)
- Immunosuppressive properties of synthetic peptides derived from CD4 and HLA-DR antigens. Mazerolles, F., Durandy, A., Piatier-Tonneau, D., Charron, D., Montagnier, L., Auffray, C., Fischer, A. Cell (1988)
- Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14. Edgeworth, J., Freemont, P., Hogg, N. Nature (1989)
- Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress. Marsh, D.C., Vreugdenhil, P.K., Mack, V.E., Belzer, F.O., Southard, J.H. Hepatology (1993)
- Calcium ionophore-induced transient down-regulation of c-myb mRNA levels in Friend erythroleukemia cells. Schaefer, A., Stöcker, U., Marquardt, H. J. Biol. Chem. (1993)
- Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells. Page, D.M., DeFranco, A.L. J. Immunol. (1988)
- Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi. Ruiz, F.A., Rodrigues, C.O., Docampo, R. J. Biol. Chem. (2001)
- Ca2+ x calmodulin prevents myristoylated alanine-rich kinase C substrate protein phosphorylation by protein kinase Cs in C6 rat glioma cells. Chakravarthy, B.R., Isaacs, R.J., Morley, P., Whitfield, J.F. J. Biol. Chem. (1995)
- Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Zwilling, S., Dieckmann, A., Pfisterer, P., Angel, P., Wirth, T. Science (1997)
- Heterogeneity of lymphocyte calcium metabolism is caused by T cell-specific calcium-sensitive potassium channel and sensitivity of the calcium ATPase pump to membrane potential. Ishida, Y., Chused, T.M. J. Exp. Med. (1988)
- Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. Bonnema, J.D., Karnitz, L.M., Schoon, R.A., Abraham, R.T., Leibson, P.J. J. Exp. Med. (1994)
- Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro. Whyte, M.K., Hardwick, S.J., Meagher, L.C., Savill, J.S., Haslett, C. J. Clin. Invest. (1993)
- Ca(2+)-dependent exocytosis in the somata of dorsal root ganglion neurons. Huang, L.Y., Neher, E. Neuron (1996)
- Cyclosporin-A sensitive induction of NF-AT in murine B cells. Venkataraman, L., Francis, D.A., Wang, Z., Liu, J., Rothstein, T.L., Sen, R. Immunity (1994)
- B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Chapoval, A.I., Ni, J., Lau, J.S., Wilcox, R.A., Flies, D.B., Liu, D., Dong, H., Sica, G.L., Zhu, G., Tamada, K., Chen, L. Nat. Immunol. (2001)
- T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome. Molina, I.J., Kenney, D.M., Rosen, F.S., Remold-O'Donnell, E. J. Exp. Med. (1992)
- Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils. Kita, H., Ohnishi, T., Okubo, Y., Weiler, D., Abrams, J.S., Gleich, G.J. J. Exp. Med. (1991)
- Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Truneh, A., Albert, F., Golstein, P., Schmitt-Verhulst, A.M. Nature (1985)
- Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. Penix, L., Weaver, W.M., Pang, Y., Young, H.A., Wilson, C.B. J. Exp. Med. (1993)
- Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation. Xiang, Z., Ahmed, A.A., Möller, C., Nakayama, K., Hatakeyama, S., Nilsson, G. J. Exp. Med. (2001)
- Adenosine diphosphate (ADP)-ribosylation of the guanosine triphosphatase (GTPase) rho in resting peripheral blood human T lymphocytes results in pseudopodial extension and the inhibition of T cell activation. Woodside, D.G., Wooten, D.K., McIntyre, B.W. J. Exp. Med. (1998)
- The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. Prieschl, E.E., Csonga, R., Novotny, V., Kikuchi, G.E., Baumruker, T. J. Exp. Med. (1999)
- Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Liao, X.C., Littman, D.R. Immunity (1995)
- Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. Leissring, M.A., Akbari, Y., Fanger, C.M., Cahalan, M.D., Mattson, M.P., LaFerla, F.M. J. Cell Biol. (2000)
- Endothelin-1 inhibits endothelin-converting enzyme-1 expression in cultured rat pulmonary endothelial cells. Naomi, S., Iwaoka, T., Disashi, T., Inoue, J., Kanesaka, Y., Tokunaga, H., Tomita, K. Circulation (1998)
- The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines. Tsatsanis, C., Patriotis, C., Bear, S.E., Tsichlis, P.N. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Bhat, N.K., Thompson, C.B., Lindsten, T., June, C.H., Fujiwara, S., Koizumi, S., Fisher, R.J., Papas, T.S. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Physical dissociation of the TCR-CD3 complex accompanies receptor ligation. Kishimoto, H., Kubo, R.T., Yorifuji, H., Nakayama, T., Asano, Y., Tada, T. J. Exp. Med. (1995)
- Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor. Bilato, C., Pauly, R.R., Melillo, G., Monticone, R., Gorelick-Feldman, D., Gluzband, Y.A., Sollott, S.J., Ziman, B., Lakatta, E.G., Crow, M.T. J. Clin. Invest. (1995)
- Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers. Liu, Y., Cseresnyés, Z., Randall, W.R., Schneider, M.F. J. Cell Biol. (2001)
- Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids. Yoshida, K., Asaoka, Y., Nishizuka, Y. Proc. Natl. Acad. Sci. U.S.A. (1992)