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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MED21  -  mediator complex subunit 21

Homo sapiens

Synonyms: Mediator complex subunit 21, Mediator of RNA polymerase II transcription subunit 21, RNA polymerase II holoenzyme component SRB7, RNAPII complex component SRB7, SRB7, ...
 
 
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High impact information on SURB7

  • Positional cloning reveals that mot encodes Med12, a component of the evolutionarily conserved Mediator complex, whose in vivo function is not well understood in vertebrates. mot/med12 transcripts are enriched in the embryonic brain and appear distinct from two other Mediator components Med17 and Med21 [1].
  • Antibody specific for the holoenzyme component hSRB7 specifically purifies BRCA1 [2].

References

  1. A subunit of the mediator complex regulates vertebrate neuronal development. Wang, X., Yang, N., Uno, E., Roeder, R.G., Guo, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. BRCA1 is a component of the RNA polymerase II holoenzyme. Scully, R., Anderson, S.F., Chao, D.M., Wei, W., Ye, L., Young, R.A., Livingston, D.M., Parvin, J.D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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