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Gene Review

DDX23  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

Homo sapiens

Synonyms: 100 kDa U5 snRNP-specific protein, DEAD box protein 23, PRP28 homolog, PRPF28, SNRNP100, ...
 
 
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High impact information on DDX23

  • We recently have shown that spliceosomal U5 small nuclear ribonucleoproteins (snRNPs) from HeLa cells contain two proteins, U5-200kD and U5-100kD, which share homology with the DEAD/DEXH-box families of RNA helicases [1].
  • In vitro phosphorylation studies demonstrated that U5-100kD can serve as a substrate for both Clk/Sty and the U1 snRNP-associated kinase, and further suggested that the multiple U5-100kD variants observed on 2D gels represent differentially phosphorylated forms of the protein [2].

References

  1. The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro. Laggerbauer, B., Achsel, T., Lührmann, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p. Teigelkamp, S., Mundt, C., Achsel, T., Will, C.L., Lührmann, R. RNA (1997) [Pubmed]
 
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