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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CDYL  -  chromodomain protein, Y-like

Homo sapiens

Synonyms: CDY-like, CDYL1, Chromodomain Y-like protein, DKFZP586C1622
 
 
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High impact information on CDYL

  • CDY genes retain CDYL exonic sequences but lack its introns [1].
  • Taken together, these data link human CDY and mouse CDYL to the histone-to-protamine transition in mammalian spermiogenesis [2].
  • Its mouse homolog Cdyl, which is autosomal, is expressed abundantly in the testis [2].
  • This progenitor later duplicated to generate CDYL and CDYL2, two autosomal genes found in all extant mammals [3].

References

  1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. Lahn, B.T., Page, D.C. Nat. Genet. (1999) [Pubmed]
  2. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Lahn, B.T., Tang, Z.L., Zhou, J., Barndt, R.J., Parvinen, M., Allis, C.D., Page, D.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Dorus, S., Gilbert, S.L., Forster, M.L., Barndt, R.J., Lahn, B.T. Hum. Mol. Genet. (2003) [Pubmed]
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