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Gene Review:

ftsL - membrane bound cell division leucine...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0084, JW0081, mraR, yabD

Guzman, L.M. et al., Daniel, R.A. et al., Daniel, R.A. et al.

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Disease relevance of ftsL

The third B. subtilis gene, yllD, is essential, as is the correspondingly positioned ftsL gene of E. coli [1].

High impact information on ftsL

Repression of ftsL in a strain engineered to carry a conditional promoter results in cell filamentation, with a near immediate arrest of cell division [2].
TnphoA topological analysis and fractionation of alkaline phosphatase fusion proteins indicated that the ftsL gene product is a 13.6-kDa cytoplasmic membrane protein with a cytoplasmic amino terminus, a single membrane-spanning segment, and a periplasmic carboxy terminus [3].
This gene, which we named ftsL, was detected through characterization of TnphoA insertions in a plasmid containing this chromosomal region [3].

References

A complex four-gene operon containing essential cell division gene pbpB in Bacillus subtilis. Daniel, R.A., Williams, A.M., Errington, J. J. Bacteriol. (1996) [Pubmed]
Characterization of the essential cell division gene ftsL(yIID) of Bacillus subtilis and its role in the assembly of the division apparatus. Daniel, R.A., Harry, E.J., Katis, V.L., Wake, R.G., Errington, J. Mol. Microbiol. (1998) [Pubmed]
FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli. Guzman, L.M., Barondess, J.J., Beckwith, J. J. Bacteriol. (1992) [Pubmed]

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