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Gene Review:

gpmA - phosphoglyceromutase 1

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0744, JW0738, gpm

Ehrmann, M.A. et al., Vassinova, N. et al., Benoit, S. et al.

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Disease relevance of gpmA

Besides known Fur-regulated genes, seven Escherichia coli loci which have not previously been shown to be Fur regulated were found, including the pgmA and nrdHIEF genes, predicted ORF yhhY and four promoters identified first in this study [1].
The deduced amino acid sequence of pgmA shows an overall similarity of 39% to the phosphoglucomutase of Lactococcus lactis. pgmA is separated by a single nucleotide from the preceding mapA gene indicating effective translation by translational coupling [2].

High impact information on gpmA

The recombinant Gpm from pSLB2 complemented E. coli strain PL225 (gpm) and restored growth on minimal glucose medium in a temperature-dependent manner [3].

References

A method for direct cloning of fur-regulated genes: identification of seven new fur-regulated loci in Escherichia coli. Vassinova, N., Kozyrev, D. Microbiology (Reading, Engl.) (2000) [Pubmed]
Maltose metabolism of Lactobacillus sanfranciscensis: cloning and heterologous expression of the key enzymes, maltose phosphorylase and phosphoglucomutase. Ehrmann, M.A., Vogel, R.F. FEMS Microbiol. Lett. (1998) [Pubmed]
Treponema pallidum 3-phosphoglycerate mutase is a heat-labile enzyme that may limit the maximum growth temperature for the spirochete. Benoit, S., Posey, J.E., Chenoweth, M.R., Gherardini, F.C. J. Bacteriol. (2001) [Pubmed]

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