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Gene Review

napD  -  assembly protein for periplasmic nitrate...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2199, JW2195, yojF
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Disease relevance of napD

  • Finally, the napD gene product is a 9.4 kDa soluble protein which is also found in E. coli and T. pantotropha [1].

High impact information on napD

  • 0. The gene encoding NapE was also sequenced and the inferred amino acid sequence from the predicted ORF was found to be 60% identical and 75% similar to that encoded by napD [2].
  • Lack of substrate specificity suggests the cloned gene, napD, encodes a nonspecific acid phosphatase with a pH optimum of approximately 6 [3].
  • 5. An R. meliloti napD transposon-insertion mutant was constructed, and its symbiotic phenotype was determined to be Fix+ regardless of the level of phosphorus provided to the host plant [3].


  1. Periplasmic nitrate-reducing system of the phototrophic bacterium Rhodobacter sphaeroides DSM 158: transcriptional and mutational analysis of the napKEFDABC gene cluster. Reyes, F., Gavira, M., Castillo, F., Moreno-Vivián, C. Biochem. J. (1998) [Pubmed]
  2. Cloning and characterization of a second acid phosphatase from Sinorhizobium meliloti strain 104A14. Deng, S., Elkins, J.G., Da, L.H., Botero, L.M., McDermott, T.R. Arch. Microbiol. (2001) [Pubmed]
  3. Cloning and characterization of a Rhizobium meliloti nonspecific acid phosphatase. Deng, S., Summers, M.L., Khan, M.L., McDermott, T.R. Arch. Microbiol. (1998) [Pubmed]
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